Structure of PDB 5xy3 Chain a Binding Site BS01 |
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| >5xy3 Chain 1 (length=2544)
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guagucugccauacgcaggaagacccgcugaacugaagcaucucauuaag
cggaggaaaagaaacuaacuaggauucccuuaguaaaggcgaucgaaaag
ggaacagcccaacgucuuaaucccgagggaaauguagucgguucaccuau
ugcacuggucuaagucagauggaaugcugcgcgauucagaguaaaagccu
cguaugaccaaccgcaagcuuacgauggaccggggagagucggauacuuu
gagaguagugucuuaagggggugguaugucccauccaaggcuaaauaacg
ugagagaccgauagauuacaaguagugugaacgaaagaugaaaagaacuc
uaaaacagagggugaaaaguuccugaacuugcuuaggguuaaggcuauuu
auaguacccgucuugaaacacggauuagggaguuuaucuguagugcgagu
cuuugcacguuaacuguaaaggcguagagaaagcaacuggcguuugcaug
gcuacugagcauuacugauaggacccgaaagguggugaacuuugccugca
cagguugaagucaggggaaacucugauggaggaccguacggguuauugau
gugcaaaucauuuuucugauguagguaaaggugcgaaagacucaucgaac
caccuaauagcugguuuccuccgaaguuucccucaggauagcuguaaugc
uaguuaaggggaguagaguauggguagagguacuuauuuccaaacuucga
accuccuuguuaggcauuuaccuaacuggaaaugcuuaaaugaauuagcg
uuacaagugggcucugaccgguaagcggucauggcgaaaugggaugaacc
auacgucugaauaaggugccgaaauguacuaucacugauaccauaaaggg
aguccauguauauacuagggccccgaaaaugaauggcgcauauaguacua
ccgaucucagacaucaguucuauugaacugagaguagggggauguggaca
uuuuugugaaggugcaaugugaguuggacuggaagaaugucuauuacaga
uccuaauugaaguagcgauuauccaggcuuguauccugggggcugaugag
gaguaggguuucuggacaacuuaaacagauccagaguuagucgauccuaa
ucucaauaaugggagaaagggaguacaguugauauucuguaacugacaac
aguucgcggcaacgcauacuauuuuucuccgccaaucuuauaccguuggu
agggaucucuuuccuacaugacaguacuaauacccagggaaacuggucau
caggcgaacugcggcguucugcuggcaaaacauagcuguuaugucaaugg
cuauuggauugguccaugaagcgaaaaauaguuuacuggucacucguacc
gauaaccgcaucaggucuucuagguaaguagccuauggccauugaggcau
gauaguucagggaauucggccaauuagagcuguaacuucgggauaaagcu
uggcucugaugaaaaucagaaccgauuguuacgcggagagcccaacuguu
uaauaaaaacguagugucgcgcugugguaguauagccagugaacgcgaca
ugaauccugcucagugcugugucuguuaauaugguucaagccaacgaagc
accgguaaauagcugggguaacuaugacucuuaucaaaguagcgaaauac
cucgucacuuaauuagugaccugcaugaacggagcuaugagguucucacu
gucccaaacugucucucagcgaaccaacuguagugggaacggucacuaga
uauccagcggggaaagaagacccuguagagcuucacuuuggucuagucuu
guauaguauuaugcuuaccuaucacaaggaauaggacuagauagaaaguu
uggcuggggcggcacaccuucgaaagagcagcgaagguguccuaaguuga
gcucagugaggacagaaaucucacguugaggauaaggccaaaagcucaau
uuacugugccuuuuuguacuaggaucaguuacgaaaguaaggccuaacga
ucccuaaauagccucaggugcgugaggauuggggugacagacaaguuacc
uccgggacaacuggcuuguggcugcuaagagaucaaaucaacgcagcuuu
uugauucuucgaugucggcucuuccuauccuagugauguacaaguugcua
agggucggauuguucacccguauuagggaucgugagcuggguuuagaccg
ucgugagccagguuuguuuuauccuacuggauauagcaucaugauaguag
auugauuuaguacgagaggaacuguugauuauggccucugguuagcgauu
aucggaaacgguaugucgcgcagcuacgccgucugggauaauggcugaaa
gccucuuaagccagaagcccaucuagaaagugaugcacuacgaauaaugg
uaacccaauguagaagacauugugugaacgaagguacuguaagcagugga
guggcaccacgaccuguugagguucagcuucgcuucuagguuuc |
........................<<<<<.....<<....>>......>>
>>>...........<<....>>..<<<<<<......<.....>.....>>
>>>>..<<<......<<...<<<<..>>>>.....>>.<<<<<<<.<..<
<<<..<<<<<.....<<<........>>>.((......<<<.....))>>
>....>>>>>...>>>>......>.>>>>>>>.........<<<<<<<..
......>>>>>>>.....<<<<<..(((([[>>>>>..>>>.........
........................<<....>>...............<<<
<.....>>>>.................................<<<<<..
>>>>>..<<<<........>>>><<<<<<....<<<<<.<<<<<<<..<<
<...<<<.......>>>...>>>.............<<<<<....>>.>>
>.......>>>>>>>.>>>>>..<<.<..<<<<<<<.....<<<<<<<<<
..<<<....<<<<<<......>>>>>>.....>>>....<<<..<<.<<.
.......>>>>.>>>....>>>>>>>>>....<.......>.......>>
>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<.
...<<<<<<<<....<<<..<<<<...<<<..>>>...>>>>..>.>>..
..>>>>>>.<<<<<<<<<<.<<.....>>>>>>>>>>>>...>>....>>
>>>>>.>>..<<<.<<<<<<.....>>>>>>.>>>...<<<<......>>
>>..<<<<<<....<<<(((.....<<<<<<....<<..........<<<
.<<<<..<<<..>>>..>>>>>>>..........))).>>..>>>>>>.>
>>....>>>>>>.<<<<<<<....>>>>>>>.....>>>>>><.<<<<<<
<<<<......<<<.<<<<....>>>>.>>>...>>>>>>>>>>..>....
.>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<
<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...
<<<<......>>>>....>>>..<<<<<........>>>>>))<<<<..<
<<<...<<....>>...<<<<<<<<<<...<<<<<<<<.<<<<<<<<<<<
<<<<...{{..>>>>>>....<<<<...<<<.<<<<<.....<<<<...>
>>>.....>>>.>>.>>>..>>>>.....<<<<<<<.>>>>>>>>>>>>>
.>>>.>>>>>>>>.........>>>>>>>>>>..>>>>>>>>.>>>..>>
.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<<...
<<<<<<<..<<...............<<<<<....<....>.....>>>>
><<.<<<<<<....>>>>>>.>>............<<<<<<<<<..<<<.
........>>>..<<<<<<<....<<<<......>>>>......>>>>>>
>...<<<.<<<..<<<<<..<..<<<<....<<<<....>>>>....>>>
>>.>>>..>>>>>.<<<<<.......>>>>>..........<........
...<<<<<<.....>>>>>>.....>....>>>....>>.>>>>>>>...
..>>..>>>>>>>>>>>>>>....>>....<<<<<........>>>>>..
<<<<<<<..<<<.<<......<<.<.<<<<<<..<<<<<.<<<<<<<<<.
<<<<<<..>>>>>>...<<<......>>>....>>>>>>>>>..>>>>>.
..<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<
<<...<<<<<<.......>>>>>>.....<<.((.((>>....>>>>>>>
...<<<.<<<<.........>>>.>>>>.<<<....>>>.>>))))....
..<<<<<....<<<<.]].))))>>>>.>>>>>..........>>>>..>
>>.>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>..
.>>..>>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>.
.>>>.<<<.........>>>....>>>>>..>...>>>.>>....<<<<<
.<....>.>.>>>>....>>..>>>.>>>>>>>..<<<<<<...<<<..<
<<<<<<.................>>>>>>><<<<<....<<<..<<<<<<
<<<.}}...>>>>.>>>>>...>>>..>>>>>..<<<.<..<<<<<....
........>>>>>...>>>>..>>>.....>>>>>>..............
.<<<<<<<<<.......>>>>>...<<<<<<<...<<<....<<<<.<..
<<<<..>>>>..>>>>>...>>>.....>>>>.>>>..>>>>.. |
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| PDB | 5xy3 Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii |
| Resolution | 3.2 Å |
Binding residue
(original residue number in PDB) | P2 T3 R4 H6 K7 S8 R9 K10 R12 G13 V15 M17 G18 F19 G20 R21 V22 G23 H25 R26 S28 P29 G30 G31 H32 G33 R34 G36 H40 Q41 R42 T43 W44 R47 Y52 F53 G54 K55 G57 M58 R59 H60 L61 H62 L63 N66 R67 T74 N76 K113 L115 A116 S133 E134 E135 |
Binding residue
(residue number reindexed from 1) | P1 T2 R3 H5 K6 S7 R8 K9 R11 G12 V14 M16 G17 F18 G19 R20 V21 G22 H24 R25 S27 P28 G29 G30 H31 G32 R33 G35 H39 Q40 R41 T42 W43 R46 Y51 F52 G53 K54 G56 M57 R58 H59 L60 H61 L62 N65 R66 T73 N75 K112 L114 A115 S132 E133 E134 |
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| Enzyme Commision number |
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