Structure of PDB 5k0y Chain a Binding Site BS01

Receptor Information

>5k0y Chain a (length=129) Species: 9986 (Oryctolagus cuniculus)

VRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFE
IIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGF
IVLTTSAGIMDHEEARRKHTGGKILGFFF

Ligand information

>5k0y Chain A (length=1776)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaa
cugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugu
gugggaugcgugcauuuaucagaucaaaaccaacccggucagcggcggcg
gcuuuggugacucuagauaaccucgggccgaucgcagcccuccguggcgg
cgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccg
ugccuaccauggugaccacgggugacggggaaucaggguucgauuccgga
gagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgc
aaauuacccacucccgacccggggagguagugacgaaaaauaacaauaca
ggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuua
acgaggauccauuggagggcaagucuggucgcagcagccgcgguaauucc
agcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguug
gaucuugagggcccgccccucggcgcccccucgaugugucccgcggggcc
cgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccg
ccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuug
uugguuuucggaacugaggccaugauuaagagggacggccgggggcauuc
guauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccag
agcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucgg
agguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugcc
gacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgg
gaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaac
uuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaa
uuugacucaacacgggaaaccucacccggcccggacacggacaggauuga
cagauugauagcucuuucucgauucugugggugguggugcauggccguuc
uuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacuc
uggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacu
ucuuagagggacaaguggcguucagccacccgagauugagcaauaacagg
ucugugaugcccuuagaugucggggcugcacgcgcgcuacacugacuggc
ucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccc
cauucgugauggggaucggggauugcaauuauuccccaugaacgaggaau
ucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuu
guacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccuc
ggaucggcccgccggggucggcccacggcccuggcggagcgcugagaaga
cggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccg
uaggugaaccugcggaaggaucauua

...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[....................<<.....
<<.<<<.....>>>.>>......>>..........<<...<<.<......
>.>>...>>..[[..(((((.....<<<<<<<<<<<<.<........>>>
>..............)))))......]]...<<<<.<<<......>>>.>
>>>....]]]...}}....]]].<<<....<<<....<<<<<<<......
...>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}
}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]]....
.....<<<....<<<.....>>>..>>>......}}.......<<<<<<<
<<.<<<....>>>.>>.>>>>.>>>......<<..<...........>..
>>.........<<<<<((......<<<<.....<<..))>>.......>>
>>.>>>>>..)))))).]]]............{{.......{{...[[[.
[[......<<.>>...........<<<<<...............>>>>>.
........<<<<<..<.......<<...<.......>.<<<<.......>
>>>...>>......>..>>..>>>.......[[....(((((((.....>
>>>>>>>>.)))))))...]]....]]....<<<<<<..<...<<<<..<
<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>......
.<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<
<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<
.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<
..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>
>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<....
..<<........>>..........<<<<<......<<<<<<.......<<
.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<<<<<<<<.
...<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<
...<...<<<<..<<<<....<<<..<<<<....>>>>.>>>....>>>>
..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>
>...>.>>>>>>>>.....>>>>>...>>.>>>>.>>>.....<<.<<<.
.......<.......<<<.<<<<....>>>>.>>>....>.........>
>>.>>............<<<<<..........>>>>>...........>>
>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>
>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<
...<<<<<.<<<<<<<<...........>>>>>>>.>...>>>>>...>>
.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<
<<<<....>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5k0y eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
• Resolution: 5.8 Å
• Binding residue (original residue number in PDB): V2 R3 M4 D9 S13 N16 R20 K22 R28 P29 C30 K32 H56 R57 K60 N70 K71 V74 S76 D80 Q82 W89 L93 T105 T106 S107 H120 G122 K124 F130
• Binding residue (residue number reindexed from 1): V1 R2 M3 D8 S12 N15 R19 K21 R27 P28 C29 K31 H55 R56 K59 N69 K70 V73 S75 D79 Q81 W88 L92 T104 T105 S106 H119 G121 K123 F129

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5k0y, PDBe:5k0y, PDBj:5k0y
• PDBsum: 5k0y
• PubMed: 27373335
• UniProt: G1TG89|RS15A_RABIT Small ribosomal subunit protein uS8 (Gene Name=RPS15A)