Structure of PDB 4v4i Chain a Binding Site BS01

Receptor Information
>4v4i Chain a (length=63) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKMKTHKGAKKRVKITASGKVVAMKTGKRHLNWQKSGKEIRQKGRKFVLA
KPEAERIKLLLPY
Ligand information
>4v4i Chain w (length=2889) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaug
aaggacguggcuaccugcgauaagccagggggagccgguagcgggcgugg
aucccuggauguccgaaugggggaacccggccggcgggaacgccggucac
cgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguaccc
agaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggg
gaccagccuaaaccguccggcuuguccgggcggggucguggggcccucgg
acaccgaauccccagccuagccgaagcuguugggaagcagcgccagagag
ggugaaagccccguaggcgaaagguggggggauaggugaggguacccgag
uaccccgugguucguggagccaugggggaaucugggcggaccaccgccua
aggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaag
gugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcu
uacaagcagucacggccccgcaagggguuguggcgugccuauugaagcau
gagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggc
guagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccg
aaaccgggcgagcuagcccuggccagggugaagcuggggugagacccagu
ggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcua
ggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaauga
cuuuagggucagccucaggcgcugacuggggccuguagagcacugauagg
gcuagggggcccaccagccuaccaaacccugucaaacuccgaaggguccc
agguggagccugggagugagggcgcgagcgauaacguccgcguccgagcg
cgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugg
uaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagc
cauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccg
aaaaugaucggggcucaagcccagcgccgaagcugcgggucugggggaug
accccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcg
agggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaa
agagggugagaaucccucucgccguaagcccaaggguuccuacgcaaugg
ucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagc
cgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggg
gacgcucuaggcuagggggaccggagccauggacgagcccggccagaagc
gcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggg
gaagcccguacgggugacaaccccccgaagccagggagccaagaaaagcc
ucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcg
ggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugc
aaguuggccccguaacuucgggagaaggggugcucccuggggugaugagc
uccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacaca
gcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggu
gccggaaggucaaggggaggggugcaagccccgaaccgaagccccgguga
acggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggg
uaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcg
agggacccggugaaauugaacuggccgugaagaugcggccuacccguggc
aggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuug
gucgcgccugcguaggauaggugggagccugugaacccccgccuccgggu
gggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaac
ccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgc
cuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaa
auccgccggagagcgcaaggguagaagggggccugacugcgaggccugca
agccgagcaggggcgaaagccgggccuagugaaccgguggucccgugugg
aagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugau
cucccccgagcguccacagcggcggggagguuuggcaccucgaugucggc
ucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgccc
auuaaagcggcacgcgagcuggguucagaacgucgugagacaguucgguc
ucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacga
gaggaccggaagggacgcaccucugguuucccagcugucccuccaggggc
auaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaag
cgggaagcccgccccaagaugaggccucccacggcgucaagccgguaagg
acccgggaagacgacccgguggaugggccggggguguaagcgccgcgagg
cguugagccgaccggucccaaucguccgaggucuugacc
<<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<......
..<<<<<<.[.[.((.>>>.....<<<<<<<..<<<)).].].>>>....
.>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<
<<<<<.....>>>>>>......<<<<<<.....<<....>>......>>>
>>.>.........<<....>>...<<<<<.....<<.....>>....>>>
>>...<<<.....<<<<<<<.....>>>>>>.>......<<<<<<<<...
..<<<...<<<<<.<<<..<<<....<<<<......>>>>.<<......(
(......>>.))...>>>....>>>.>>>>>...>>>.>>>>>.>>>...
..<<<...<<.........>>...>>>......<<<<<..<<<<>>>>>.
.>>>......>>.>>>>>>.>>...............<......>....>
>.........<<<<....>>>>..................>>>>>>>>>>
>.......<<<<<<<<<<<....>>>>>>>>>>>................
..<<<<<<....<<<..<<<<<<<<..<<<...<<.......>>...>>>
...<<....>>..<<<<.....>>>>.....>>>>>>>>..>>>..<<.<
..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>
.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>...>...>>>..<<<<<<....<<<
<<....>>>>><.<<<<<<<.....<<<<<<<<<...<<<...<<<<.<<
<.<.<<<<<<......>>>>.>>>..>>>.>>>>..>>.>...>>>>>>>
>>.....>>>>>>>..>..<<<<<<<.<<......>>.>>>>>>>.....
<<<......>>>...<<<<.<<<...<<<((......<<<<<<.......
....<<..<<.<<<<<.........<<<<<.<<...<<<<.......>>>
>...>>.......<.<<......>>.>.>>>>>.....>>>>>.>>.>>.
..........))......>>>>>>.>>>...>>>>>>><<<<<.<<....
.>>.>>>>>....>>>>>>.<<<<<<...<<.......<<<<<.<<<...
.>>>>>>>>....>>..>>>>>.>......>>>>>>.......<......
.<<<<<.......>>>>>.<<<<....<<<<..<<...<<<<<<...<<.
....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>
>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<....<<<.
...<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<
<<<<<<<<<<<<<<.<.......>>>>>>>>....>>>>>>>>>..>>>.
..<.<<......>>>......>>>>>...>>>..>>>>>.........>>
>....>>...>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.
<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........
......<<<<<...............>>>>><<<<<<<.<<<<.....>>
>>.>>>>>>>............<<<<<<<<<...<<.........>>...
<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<....
.<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>...
..>>><<<<<.........>>>>>....................<<<<<.
......>>>>>..........>>>>...>>.>>>>>>>.....>>.>>>>
>>>>.>>>>.>...........<<<<<........>>>>>..<<<<<<<<
.<<..<<......<<<<.<<<<<<..<<.<..<<<.<<<<<.<<<<...<
<<<<<<<<...........<<<<<..<<<<.....<<<<<<<<....>>>
>>>>>..>>>>............>>>>>..>>>>>>>>>...>>>>...<
<<<<....>>>>>....>>>>>.>>>...>.>>..<<<<.....>>>><<
<<<<...........>>>>>>..<<...<<<<<<....<<<<<<......
.>>>>>>.....<<...(((>>.....>>>>>>...<<<<..<<<.....
.>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>
..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...
<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<
..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>
>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....
>>...>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<........
.......>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>
>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>
>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<
<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>
>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4v4i Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements
Resolution3.71 Å
Binding residue
(original residue number in PDB)		P2 K3 M4 K5 T6 H7 K8 K11 K12 K15 T17 A18 S19 T27 K29 R30 H31 L32 N33 W34 Q35 G38 K39 I41 R42 K47 F48 V49 L50 A51 K52 L61 L62 P63
Binding residue
(residue number reindexed from 1)		P1 K2 M3 K4 T5 H6 K7 K10 K11 K14 T16 A17 S18 T26 K28 R29 H30 L31 N32 W33 Q34 G37 K38 I40 R41 K46 F47 V48 L49 A50 K51 L60 L61 P62
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4v4i, PDBe:4v4i, PDBj:4v4i
PDBsum4v4i
PubMed16962654
UniProtQ5SKU1|RL35_THET8 Large ribosomal subunit protein bL35 (Gene Name=rpmI)

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