Structure of PDB 5juo Chain ZA Binding Site BS01

Receptor Information
>5juo Chain ZA (length=217) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GWVPVTKLGRLVKAGKITTIEEIFLHSLPVKEFQIIDTLLPGLQDEVMNI
KPVQKQTRAGQRTRFKAVVVVGDSNGHVGLGIKTAKEVAGAIRAGIIIAK
LSVIPIRRGYWGTNLGQPHSLATKTTGKCGSVTVRLIPAPRGSGIVASPA
VKKLLQLAGVEDVYTQSNGKTRTLENTLKAAFVAIGNTYGFLTPNLWAEQ
PLPVSPLDIYSDEASAQ
Ligand information
>5juo Chain A (length=1781) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguu
ggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagucc
uuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguu
caaagcaggcguauugcucgaauauauuagcauggaauaauagaauagga
cguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagg
gacggucgggggcaucaguauucaauugucagaggugaaauucuuggauu
uauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaa
ucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucu
uaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacc
cacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguau
ggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggag
uggagccugcggcuuaauuugacucaacacggggaaacucaccaggucca
gacacaauaaggauugacagauugagagcucuuucuugauuuugugggug
guggugcauggccguucuuaguugguggagugauuugucugcuuaauugc
gauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcug
guuauccacuucuuagagggacuaucgguuucaagccgauggaaguuuga
ggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgc
uacacugacggagccagcgagucuaaccuuggccgagaggucuugguaau
cuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuu
caacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgu
cccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuua
gugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcg
gagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaag
guuuccguaggugaaccugcggaaggaucau
...<<<<..{.[[[[.>>>><<<<.<<<<<......<..........<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<..................<.....<<
..<.......>..>>......>.........<<<<<............>>
>>><...<<<<<<......((((((..<<......>>.............
.>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>
>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.......
...>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<
.....>>>..>>>.......>.......<<.<<<<<..............
>>>>>..>>......<<..<...........>..>>.........<<<<<
((....<.<<<<.....<<..))>>.......>>>>>>>>>>...>>>>>
>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<
<.....<..>.....>>>>.>>>>>>.....<<<<<..............
.................>>>>>....<<<<<.<<.......<<...<...
....>..<<<.....>>>....>>......>>.>>..>>>..........
....<.<<<<<.......))))))..>>>>>.>.........>>....<<
.<<<.<<...<<<<..<<<.<<<<<<.....<<<......>>>.......
.>>>>>.>>>>.......<<....>>...>>>>..>>.>>>..>>...>>
>...>>.>....<<.<<.....<...<<<<.<.....>.>>>>...>..>
>.>>..........<<<.<<.<<.<.<<<<<<<<.<<<........>>>>
>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......
<<<......>>>....>>>..]]]].}.<<<<.<<<<<<<..<<.<<<<<
...<<<.<<<<<<......<<........>>..........<<<<<.<..
..<<<<<........<<..<..........>..>>......>>>>>...<
<.<<<....<<<<<<.....<<<.<<<<......>>...<<<......>>
>...>>.>>>....<<<<..<<..<.<<..<<<<<.<<<<<<....>>>>
>>...>>>>>..>>.>.>>....<<<<<<.....>>>>>>........>>
>>.....>>.>>>...>...>>>>>.....>.>>>>>...>>.>>>>.>>
>.....<<<<<<<......<<.....<<...<<<....>>>...>>....
>>.......>>>>>>>......<....<<<<<<..........>>>>>>.
...>......>>>>>....<<<<<<<<.......>>>>>>>>......>>
...>>>>>>>>>>.>........<<....<<<<.<<....<<<<<<<<.<
<<....<<......<<<<<<..<..<..<.......>...>..>..>>>>
>>......>>....>>>.>>>>>>>>...>>.>>>>.....>>.......
...<<<<<<<<....>>>>>>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5juo Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		V86 Q87 K88 Q89 T90 R91 A92 Q94 R95 K99 T159 K161 S164 R168 I170 V179 A180 Y197 T198 Q199 S200 N201 K203 T204 R205 T206
Binding residue
(residue number reindexed from 1)		V53 Q54 K55 Q56 T57 R58 A59 Q61 R62 K66 T126 K128 S131 R135 I137 V146 A147 Y164 T165 Q166 S167 N168 K170 T171 R172 T173
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0070181 small ribosomal subunit rRNA binding
Biological Process
GO:0000054 ribosomal subunit export from nucleus
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0042254 ribosome biogenesis
GO:0045903 positive regulation of translational fidelity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5juo, PDBe:5juo, PDBj:5juo
PDBsum5juo
PubMed27159452
UniProtP25443|RS2_YEAST Small ribosomal subunit protein uS5 (Gene Name=RPS2)

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