Structure of PDB 6hcj Chain Z3 Binding Site BS01

Receptor Information
>6hcj Chain Z3 (length=135) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPR
KVTAAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVF
RDPALKRKARREAKVKFEERYKTGKNKWFFQKLRF
Ligand information
>6hcj Chain 51 (length=3635) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaau
guggcguacggaagacccacuccccggcgccggggggcccaaguccuucu
gaucgaggcccagcccguggacggugugaggccgguagcggcccccggcg
cgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaa
agcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauag
ucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguuc
aagagggcgugaaaccguuaagagguaaacgggugggguccgcgcagucc
gcccggaggauucaacccggcggcgcgguccggccgugccggcggggcgg
aucucccgcucccgucggcgggggaccgccccccggccggcgaccggccg
ccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggac
ggcugggaaggccccggcggggaagguggcccgggggccccggguguuac
agccccgccccggcagcagcagcucgccgaaucccggggccgagggagcg
agacccgugcgccgcgcucuccccccucgggggggccgggccaccccucc
cacggcgcgaccgcucucccacccggggggcggggcggacuguccccagu
gcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggc
cacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccac
ccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucg
ggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcg
ccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcac
caccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacg
uguuaggacccgaaagauggugaacuaugccugggcagggcgaagccaga
ggaaacucugguggagguccguagcgguccugacgugcgaaucggucguc
cgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguu
cccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccg
guaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauuc
ucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcg
uggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcug
cgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucag
accccagaaaagguguugguugauauagacagcaggaugguggccaugga
agucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacua
gcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgc
uggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgac
gaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccgg
guggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaac
gagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguug
aacaugggucagucgguccugagagaugggcgagcgccguuccgaaggga
cgggcgauggccuccguugcccucagccgaucgaaagggagucggguuca
gauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugc
gguaacgcgaccgaucccggagaagccggcgggagccccggggagaguuc
ucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagag
aggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagc
ucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgg
gccguacccauauccgcagcaggucuccaaggugaacagccucuggcaug
uuggaacaauguagguaagggaagucggcaagccggauccguaacuucgg
gauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggac
caggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcgg
cggguguugacgcgaugugauuucugcccagugcucugaaugucaaagug
aagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucu
uaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggau
gaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaa
gggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuug
acucuagucuggcacggugaagagacaugagagguguagaauaaguggga
ggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugac
ccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcc
cggccggccgggcgcgacccgcuccggggacagugccagguggggaguuu
gacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgag
cucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuu
gaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgau
ccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccaca
gggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuug
auccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagc
guuggauuguucacccacuaauagggaacgugagcuggguuuagaccguc
gugagacagguuaguuuuacccuacugaugauguguuguugccaugguaa
uccugcucaguacgagaggaaccgcagguucagacauuugguguaugugc
uuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacug
aacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagcc
ucgguuggccucggauagccggucccccgcccgggguccggugcggagag
cccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcc
cgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguaga
cgaccugcuucugggucgggguuucguacguagcagagcagcugcugcga
ucuauugaaagucagcccucgacacaaggguuugu
.........................<<<<<<.....<......>......
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..>>>.>..<<<.<<<<<....<<<..<<<..<<<<<<<<....<<<<..
....>>>>.............<<<.......>>>...>.>>>>>>>...>
>>..>>>...>>>>.>>>>.......<<<<<<<........>>>>>>>..
....<<<<..(((((.>>>>...>>>........................
..........<<....>>...............<<<......>>>.....
.............................<<<<<<<<..<<..<....<<
<<<<<<.........<<<<<<<<<<....<<<<<<<.<<....<<<<<<<
.<<<<<<<<<......>>>>>>>>>>>>>>>>...>>>>>>...>>>.>>
>>>>>>>>..........>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<
<<<.........<..<<<<<<.......<<<<.<<<.>>>.>>>>.....
...>>>>>>...>............>>>>...>>>>>>>>>>.....<<.
......>>.............<<<<<<..>>>>>>...<.<<.<<<<.<<
<<<<<...<<<<<<....<..<<...>>>.<<<<<<<...<<....>>..
.>>>>>>>.>>.>>>>...>>>>.>>>...>.>>>...........>>.>
..........................>>.>>>>>....>.>>...>>>>>
>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<.
..<<<.......>>>.....>>>...<<....>>...<<<<<<<<<<..>
>>>>>>>>>..<<<<<...<<<..<<........[...>>..>>>....>
>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>
>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<...<<.......<<.
<.....>>>........>>....<<<..<..<<........>>.>.>>>.
...>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..
<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<.
...<<<....<<<...<<<<..<<<.<<.........>.>>>>>>>.>..
>>>...>>>....>>>>>>...<<<<<<<<<.<......>>>>>>>>>>.
...>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....
<<<......>>>...<<<<<<<...<<.(((.......<<<<<.....<<
..........<<<.<<<..<<<.....................<<.....
....>>...............<<......>>.............>>>..>
>>>>>..........))).>>...>>>>>...>>...>>>>>>><<<<<.
.<<<.....................]................>>>.>>>>
>....>>>>>>..<<<<<<<<..<<......<<<<.<<<<....>>>>>>
>>...>>.>>>>>>>.>......>>>>>><<<....<<.....<<<<<<.
......>>>>>>.<<......<<.<..<<...<<<<<<...<<.....>>
.>>>>>>....(.<<<<<<...<<....<<<....>>>............
.<<<<<.<<<...>>>.>>>>>........>>....>>>...<<<<....
....>>>>..)<<<<....<<<......<<<<<......>>>>>....<<
<....>>>......<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[
[[..>>>>>>.....<<<..<<<<.<<<<.....<<<.....>>>.....
>>>>>>>>...>>>......<<<<<<<.......>>>>>>>>>>>.>.>>
>>>>>>>>>>.........>>>>>>>................>>>.>>>>
.>>>..>>.....<<......>>.>.>>.<<<<.....>>>>...>>...
.<<<<.....<<<<<<..<<...............<<<<<..........
.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>.........
...<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....
.>>>>......>>>>>>>..<.<..<<<..<<<<<.....<<<......<
<<....>>>......>>>..>>>..>>>>><..<<.........>>...>
.......<...........<<<<<.......>>>>>.....>.....>..
>..>>.>>>>>>>.....>>..>>>>>>..>>>>>>...>>>....<<<<
<........>>>>>.....<<<<..<<<.<<......<<<<....<<<..
<<<<..<<<<<<<<..<<<.<<<<...<.<<<<..........<<<<<..
.<<<..>>>.............>>>>>.>>>>.>...>.>>.>>>>...<
<<<<.....<<<<.................................<<<<
<.<<..>>.>>>>>...>>>>..>>>>>.....>>>>>>>>...>>>>..
..<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<
<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>.
..<<.<<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....
.<<<<<<..<<<...))))).>>>>>>>>>..........>>>.....>>
>>.......<<..<<.<<<<<<...<<.......>>...>>>>>>...>>
.>.>.........<<<.<.<<<...<...<<<<<......>>>>>.....
>.<<<.........>>>......>>>...>...>>>.......<<<<<<<
....>>>.>>>>....>>..>>>.>>>>......<.<<<<....<<<..<
.<<<<<.................>>>>>.><<<<....<<<<....<<..
<.<<<.]]]..>>>....>.>>...>>>>...>>>><<<.....<<<<..
...........>>>>.....>>>.>>>.....>>>>.>.<<<<<<<..<<
<.....<<.........<<<<<....<<<..>>>...>>>>>........
>>...<<<..<<<<....<<<.<<<<<........>>>>>..>>>...>>
>>..>>>...............>>>..>>.>>>>>.<<<<<.<.......
......>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..
>>>>>....>>....>>>>.>>>.>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hcj ZNF598 Is a Quality Control Sensor of Collided Ribosomes.
Resolution3.8 Å
Binding residue
(original residue number in PDB)
G16 R17 R36 Y38 R48 K59 K64 K67 K73 N76 H79 K107 R108 R112 K115 R135
Binding residue
(residue number reindexed from 1)
G15 R16 R35 Y37 R47 K58 K63 K66 K72 N75 H78 K106 R107 R111 K114 R134
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006364 rRNA processing
GO:0006412 translation
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6hcj, PDBe:6hcj, PDBj:6hcj
PDBsum6hcj
PubMed30293783
UniProtG1TXF6|RL27_RABIT Large ribosomal subunit protein eL27 (Gene Name=RPL27)

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