Structure of PDB 8p4f Chain Z Binding Site BS01

Receptor Information
>8p4f Chain Z (length=488) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYI
YVEAYKQTHVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKP
KSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKAPPQRLFD
AEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLS
ELEKFREHNFQPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDM
LEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVILFSDLTMHE
LKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPQTVGVIVRLERETFQV
LNMYGKVVTVRHQAVTRKKDNRFAVALDSEQNNIHVKDIVKVIDGPHSGR
EGEIRHLFRSFAFLHCKKLVENGGMFVCKTRHLVLANELIGQTVRISQGP
YKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVG
Ligand information
>8p4f Chain P (length=29) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucaaaaagacauacauaaagaccaggc
.............................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8p4f Structural insights into human co-transcriptional capping.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		K579 R619
Binding residue
(residue number reindexed from 1)		K369 R409
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006354 DNA-templated transcription elongation
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006368 transcription elongation by RNA polymerase II
GO:0016239 positive regulation of macroautophagy
GO:0032784 regulation of DNA-templated transcription elongation
GO:0032785 negative regulation of DNA-templated transcription, elongation
GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0034243 regulation of transcription elongation by RNA polymerase II
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0140673 transcription elongation-coupled chromatin remodeling
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0032044 DSIF complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8p4f, PDBe:8p4f, PDBj:8p4f
PDBsum8p4f
PubMed37369200
UniProtO00267|SPT5H_HUMAN Transcription elongation factor SPT5 (Gene Name=SUPT5H)

[Back to BioLiP]