Structure of PDB 7ttu Chain Z Binding Site BS01

Receptor Information

>7ttu Chain Z (length=121) Species: 1280 (Staphylococcus aureus)

GYRKLGRTSDQRKAMLRDLATSLIISERIETTEARAKEVRSVVEKLITLG
KKGDLASRRNAAKTLRNVEILNEDETTQTALQKLFGEIAERYTERQGGYT
RILKQGPRRGDGAESVIIELV

Ligand information

>7ttu Chain 1 (length=2684)

uaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaa
ggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugau
ccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucg
auaugugaauacauagcauaucagaaggcacacccggagaacugaaacau
cuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcg
agcgaaacgggaagagcccaaaccaacguugggguuguaggacacucuag
uuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaag
guaauaauccuguagucgaaaauguugucucucuugaguggauccugagu
acgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaa
ggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaag
gugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcu
uacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaau
gaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagcc
guagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccg
aaaccaggugaucuacccuuggucagguugaaguucagguaacacugaau
ggaggaccgaaccgacuuacguugaaaagugagcggaugaacugagggua
gcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauag
cuuuagggcuagccucaagugaugauuauuggagguagagcacuguuugg
acgagcgaauucagacaaacuccgaaugccaauuaauuuaacuugggagu
cagaacaugggugauaagguccguguucgaaagggaaacagcccagacca
ccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugc
cacagagugacacugcgccgaaaauguaccggggcuaaacauauuaccga
agcuguggauugucgacaaugguaggagagcguucuaagggcguugaagc
augaucguaaggacauguggagcgcuuagaagugagaaugccggugugag
uagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccag
aggaaggcucguccgcucuggguuagucggguccuaagcugaggccgaca
ggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucgu
aucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcac
gucuaagcaguaaggcgcugagcugugauggggagaagaccuucgagucg
uugauuucacacugccgagaaaagccucuagauagaaaauaggugcccgu
accgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagc
gaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaag
gggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaa
gcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugaugua
uaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcu
ucugcgaagcuacgaaucgaagccccaguaaacggcggccguaacuauaa
cgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacga
aaggcguaacgauuugggcacugucucaacgagagacucggugaaaucau
aguaccugugaagaugcagguuacccgcgacaggacggaaagaccccgug
gagcuuuacuguagccugauauugaaauucggcuuucuaacccgcaccac
uuaucguggugggagacagugucaggcgggcaguuugacuggggcggucg
ccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguugga
aaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuac
aagucgagcagggucgaaagacggacuuagugauccggugguuccgcaug
gaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuua
ucucccccaagaguucacaucgacggggagguuuggcaccucgaugucgg
cucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcc
cauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggu
cccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacg
agaggaccgggauggacauaccucugguguaccaguugucgugccaacgg
cauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaag
caugaagccccccucaagaugagauuucccaacuucgguuauaagauccc
ucaaagaugaugagguuaauagguucgagguggaagcauggugacaugug
gagcugacgaauacuaaucgaucgaagacuuaau

<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......
<<<<<<.[...((.>>>.....<<<<<<<..<<.))...]..>>.....>
>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<
<<<<<<.........>>>>>>>.>>.>>....<<<<<......<<....>
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<..>>>>......<<<<<.......
........<.<<<<<<<.<<<...<<<<<......>>>>>((......<<
<.....))>>>...>>>...>>>>>>>..>.........>..>>>>....
.<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..
)))......]].>>>>>>>.]]...............<<....>>....]
].........<<<<....>>>>.............}....>>>>>>>>>>
>.......<<<<..<<<<......>>>>..>>>>...<.<........>.
>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>
...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<
...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>
.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<
<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<
<........>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>
..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<
<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<.<<.
.......>>.>.>>>>.>>...........))).....>>>>>>.>>>..
.>>>>>>><<<<<..>>>>>....>>>>>><.<<<<<<<.<<......<<
<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><....
..<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<
<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....
>>>...>>>...>>...<<<<<........>>>>>))<<<<<<.......
.<<...<<<<....<<<<...<<...<......<<<.........>>>..
.<....<<<<...<<..>>...>>>>.....>..................
.>....>>...>>>>.........>>>>..>>.......>>>>>>>>>>.
.>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<.
...<<<<<<<<.<<...............<<<<<....<<..>>.....>
>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<
<<<..<<<.........>>>..<<<<<<<.....<<......>>......
.>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<.
...>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>
>>>>>........<...........<<<<<<.....>>>>>>.....>..
..>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>.....>..
...<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[
[<<<<..<<<<<.<<<<<<<<..<<<<......>>>>....<<.<<<<<<
.....>>>>>>>>......>>>>>>>>..>>>>>..<<<<.....>>>><
<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.....
..>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<....
..>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>
>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<
.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<
<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>
>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>...
.]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.......
........>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<....>>>>
>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>
>>>....>>>.>>>>.......>>>>>>>.<<<....>>>....<<<<<<
<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>.
..>>>..>>>>>.>>>...>>>>....>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ttu A Structurally Characterized Staphylococcus aureus Evolutionary Escape Route from Treatment with the Antibiotic Linezolid.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): G2 R4 K5 L6 G7 S10 Q12 I30 T32 T33 A35 R36 E39 S42 E45 K46 R59 R60 Q83 R96 Q97 G98 R102 R109 R110 D112
• Binding residue (residue number reindexed from 1): G1 R3 K4 L5 G6 S9 Q11 I29 T31 T32 A34 R35 E38 S41 E44 K45 R58 R59 Q82 R95 Q96 G97 R101 R108 R109 D111

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ttu, PDBe:7ttu, PDBj:7ttu
• PDBsum: 7ttu
• PubMed: 35736238
• UniProt: Q2FW33|RL17_STAA8 Large ribosomal subunit protein bL17 (Gene Name=rplQ)