Structure of PDB 7ase Chain Z Binding Site BS01

Receptor Information
>7ase Chain Z (length=175) Species: 5693 (Trypanosoma cruzi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIVRSRLHKRKITGGKTKIHRKRMKAELGRLPAHTKLGARRVSPVRARGG
NFKLRGLRLDTGNFAWSTEAIAQRARILDVVYNATSNELVRTKTLVKNCI
VVVDAAPFKLWYAKHDELKRKWMLRRENHKIEKAVADQLKEGRLLARITS
RPGQTARADGALLEGAELQFYLKKL
Ligand information
>7ase Chain 0 (length=2150) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcauugcaggaaucugcgcauggcucauua
caucagacguaaucugccgcaaaaaucuugcggucuccgcaacauuggau
aacuuggcgaaacgccaagcuaauacaugaaccaaccggauguucucugu
uccggcggcagggcaaccugcugccaugggacguccagcgaaugaaugaa
aguaaaaccaaugccuucaccggcaguaacacucagaaguguugauucaa
uucauuccgugcgaaagccggguuuuuuuauccggcgucuuuugacgaac
aacugcccuaucagccagcgauggccguguaguggacugccauggcguug
acgggagcgggggauuaggguucgauuccggagagggagccugagaaaua
gcuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugucaaa
aaaaaaagaugaggcagcgaaaagaaauagagccgacagugcuuuugcau
ugucguuuucaaugggggauauuuaaacccauccaaaaucgaguaacaau
uggaggacaagucuggugccagcacccgcgguaauuccagcuccaaaagc
guauauuaaugcuguugcuguuaaaggguucguaguugaauugagggccu
cuaaggcgcaaugguuuagucccauccacuucggauuggugacccaugcc
cuugugguccgugaacagacauucagaaacaaaaaacacgggagugguac
cuuuccugauuaucgcaugucaugcaugccagagggcgcccgugauuuuu
uacugugacuaaaaaagugugaccaaagcagucauucgacuugaauuaga
aagcaugggauaacaaaggagcagccucugggccaccguuucggcuuuug
uugguuuuaaaaguccauuggagauuauggggcagugugacaagcggcug
ggugcacucgucgccuuugcaacucacggcauccaggaaugaaggagggu
aguucgggggagaacguacuggugcgucagaggugaaauucuuagaccgc
accaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaauc
aagaaccaaaguguggggaucgaagaugauuagagaccauuguaguccac
acugcaaacgaugacacccaugaauuggggaguuuuuggucguaggcgug
gucgggcuugauuauuauuuuucaucccguuccucgucucgccaaugaau
auuaaauuuacgugcauauucuuuuuggucuucguuuuuuuacggcgagg
gccuuuaacgggaauauccucagcacguuaucugacuucuucacgcgaaa
gcuuugagguuacagucucaggggggaguacguucgcaagagugaaacuu
aaagaaauugacggaauggcaccacaagacguggagcgugcgguuuaauu
ugacucaacacggggaacuuuaccagauccggacagggugaggauugaca
gauugaguguucuuucucgauccccugaaugguggugcauggccgcuuuu
ggucgguggagugauuuguuugguugauuccgucaacggacgagauccaa
gcugcccaguaggauucagaauugcccccuuccgcggguuuuacccaagg
gggggcgguauucgcuuguauccuucucugcgggauuccuuguuuugcgc
aaggugagauuuugggcaacagcaggucugugaugcuccucaauguucug
ggcgacacgcgcacuacaaugucagugagaacaagaaaaacgacucuugu
cggaccuacuugaucaaaagagugggaaaaccccggaaucacguagaccc
acuugggaccgaguauugcaauuauuggucgcgcaacgaggaaugucucg
uaggcgcagcucaucaaacugugccgauuacgucccugccauuuguacac
accgcccgucguuguuuccgaugauggugcaauacaggugaucggacagu
cgagugcuucacuugaccgaaaguucaccgauauuucuucaauagaggaa
gcaaaagucguaacaagguagcuguaggugaaccugcagcuggaucauuu
...<<<<<...{{{{>>>>>{{{{.[[[[[[...[[[..........[[[
.[[[..<<....<<....<<<<...>>>>...>>.>>......{{.....
...[[[..[[..[[...[[.[[.....<<<<<<...>>>>>>...<<...
..<<<<<<.....>>>>>>......>>..........<<<<<.<<<....
...<<<<<<<<<....>>>>>>>>>...>>>>>>>>.[[((((((((...
...<<<<<<<<<<<<......>>>.........................)
)))))))...]]....<<<<<<........>>>>>>...]].]]..]]]]
..]]].<<<....<<<....<<<<<.<<.......>>.>>>>>>>>....
..>>>..<<<<<<<<....>>>>...>>>>.}}.<<.<<<..........
>>>.>>.<<<<....>>>>...]]]]]].........<<<....<<<...
.......>>>..>>>.......]]]....<<<.<<<<<<<<<....>>>>
>>>>>..>>>.....<<<<............>>>.....>.........<
<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..]]
]]]]}}}}.........{{{{{.....[[[[...[[[.......<<<<<.
<.<<<<.<<<..<<............................>>..>>>>
>>>>.>>>>>..........................<<<<<<..<....<
<<<.<.........<<<<.......>>>>..>>>>>.>>>>>>>.....<
<<<<<<<.......<<...<.......>..<<<....>>>.....>>...
...>>>>>..>>>...........[[..(((((..<<<...>>>.((..>
>>>>>>>>))..)))))..]].......<<<<<...<<<....<<<<<..
<<<..>>>.>>>>>..<<<>>>..>>>.>>.>>>............<<<<
<..<<...<<<<<<<<..<<<<<<<<...<<<......>>>......>>>
>>>>.>.>>.......<<....>>.>>>>>>..>>.>>>.>>....]]].
..]]]]...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>
>>>.........<<<.<<...<..<<<<<.......<<<.<<.<<<<<.<
<..<<<...<............>..>>>...>>.>>>>>>>>>>......
.....................<.<<...<<<<<<<.........>>>>>>
>.........>>.>................>>>>>..>......<<..}}
>>.....>>.....>>>.}}}.<<<......<<<<....>>>>....>>>
..}}}}..<<<<<.<<<<<<<..<<.<<<<<<.....<<<<<<.......
<<........>>.......<..<<.<<......<.<<<........<<.<
<<........>>>.>>......>>>.>.<.<<.<<<..<<.<<<<<<...
.<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<
.<<<<.....<<<<<.<<..<.....<<<<<<<..<<<<...>>>>..>>
>>>>>......>....>>.>>>>>.....>>>>...<<.<.<<.....>>
>.>>.......>>>>>....>>>.>>>.....>>>>>>>>......>.>.
>>.>...>.>>>>>....................................
....<<<<<<<........>>>>>>>........................
....<....<<<.<<..........>>.>>>.....>.....>>>>>>..
..<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.
...<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<...<.<<
<<<<<<...>>>>>>>>.>...>.>>>>>..>>>>.>.>>>.>>..>>>>
>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ase Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts.
Resolution3.33 Å
Binding residue
(original residue number in PDB)
G2 R5 S6 R7 H9 K10 R11 K12 I13 T14 G15 G16 K19 H21 K23 R24 K26 L29 R31 R41 R42 S44 R47 A48 R49 G50 F53 K54 L55 R56 N64 A71 I72 A73 Q74 R75 T86 S87 V97 K98 N99 D157 R166 T190 R192 Q195 R198 D200
Binding residue
(residue number reindexed from 1)
G1 R4 S5 R6 H8 K9 R10 K11 I12 T13 G14 G15 K18 H20 K22 R23 K25 L28 R30 R40 R41 S43 R46 A47 R48 G49 F52 K53 L54 R55 N63 A70 I71 A72 Q73 R74 T85 S86 V96 K97 N98 D116 R125 T149 R151 Q154 R157 D159
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7ase, PDBe:7ase, PDBj:7ase
PDBsum7ase
PubMed33357443
UniProtQ4DU83

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