Structure of PDB 6wmr Chain Z Binding Site BS01

Receptor Information

>6wmr Chain Z (length=470) Species: 376619 (Francisella tularensis subsp. holarctica LVS)

LKGKTSDPIRMYMREMGIVDLLDKKGETDIAIRIEEGTTEVFSTILSYPI
VIKTYIERFRELEEKAIDYMNSENEPVARYIRFNETQRAYEFFTNLEKMF
EEYQDKPNKKLYTKIVKEFDNLRLSTSHLQKLVDYIRLPYARVKEFERKI
LRLCVERSKTPRQEFIKVYKVGSLEWLEPLTKKYKFTENTIREIKNLTKQ
INQFQILMMMDIEELKQVNLEISRSEAKITQAKKEMIEANLRLVVSEAKK
YTNRGLHFLDIIQEGNIGLMKAVDKFDYRKGFKFSTYATWWIRQAITRSI
ADQARTIRVPVHMIETINKVNRIKRQILQEKGREATEEEIIEHTPNMSKE
KLKKILNISHTPISMESPIGDDEDSTVGDFIEDKNNYSPIEAANLENLRE
AIKELIETGLTEREAKVLMMRFGIGMNTDHTLEEVGKQFNVTRERIRQIE
AKALRKLKHPSRSAFLKTFL

Ligand information

>6wmr Chain G (length=35)

ttgtgttattggcgttattaaggtaacttgcttat

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6wmr Structural Basis for Virulence Activation of Francisella tularensis.
• Resolution: 3.46 Å
• Binding residue (original residue number in PDB): M92 L100 N347 R349 S353 K356 F383 D384 F389 K390 S392 T393 T396 W397 W398 Q401 R415 P417 H419 E551
• Binding residue (residue number reindexed from 1): M13 L21 N240 R242 S246 K249 F276 D277 F282 K283 S285 T286 T289 W290 W291 Q294 R308 P310 H312 E444

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0016987 sigma factor activity

Biological Process

• GO:0006352 DNA-templated transcription initiation
• GO:0006355 regulation of DNA-templated transcription
• GO:0010468 regulation of gene expression
• GO:2000142 regulation of DNA-templated transcription initiation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6wmr, PDBe:6wmr, PDBj:6wmr
• PDBsum: 6wmr
• PubMed: 33217319
• UniProt: A0A0B3WH85