Structure of PDB 5v08 Chain Z Binding Site BS01

Receptor Information
>5v08 Chain Z (length=343) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEPT
DRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLK
GKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEAD
AQLAYLNKAGIVQAIITEDSALLAFGCKKVILKMDQFGNGLEIDQARLGM
CRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLRLANNPDIVK
VIKKIGHYLKMNITVPEDYINGFIRANNTFLYQLVFDPIKRKLIPLNAYE
DDVDPETLSYAGQYVDDSIALQIALGNKDINTFEQIDDYNPDT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5v08 Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Resolution2.812 Å
Binding residue
(original residue number in PDB)		I40 F58 R121 R231 G232 I233 G234 A236 K237
Binding residue
(residue number reindexed from 1)		I38 F56 R119 R229 G230 I231 G232 A234 K235
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0035312 5'-3' DNA exonuclease activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5v08, PDBe:5v08, PDBj:5v08
PDBsum5v08
PubMed28533382
UniProtQ9UQ84|EXO1_HUMAN Exonuclease 1 (Gene Name=EXO1)

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