Structure of PDB 5sva Chain Z Binding Site BS01

Receptor Information
>5sva Chain Z (length=469) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAVIGGDNEREEEDDDIDAVHSFEIANESVEVVKKRCQEIDYPVLEEYDF
RNDHRNPDLDIDLKPSTQIRPYQEKSLSKMFGNGRARSGIIVLPCGAGKT
LVGITAACTIKKSVIVLCTSSVSVMQWRQQFLQWCTLQPENCAVFTSDNK
EMFQTESGLVVSTYSMVANTRNRSHDSQKVMDFLTGREWGFIILDEVHVV
PAAMFRRVVSTIAAHAKLGLTATLVREDDKIGDLNFLIGPKLYEAIANVQ
CAEVWCPMTAEFYQEYLRETARKRMLLYIMNPTKFQACQFLIQYHERRGD
KIIVFSDNVYALQEYALKMGKPFIYGSTPQQERMNILQNFQYNDQINTIF
LSKVGDTSIDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNA
FFYSLVSKDTQEMYYSTKRQAFLVDQGYAFKVITHLHGMENNLAYASPRE
RRELLQEVLGDDADNSVGR
Ligand information
>5sva Chain m (length=62) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tgtatgtacaacacacatcggaggtgaatcgaacgttccatagctattat
atacacagcata
Receptor-Ligand Complex Structure
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PDB5sva Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex.
Resolution15.3 Å
Binding residue
(original residue number in PDB)		T412 S414 M459 R785
Binding residue
(residue number reindexed from 1)		T119 S121 M166 R469
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000019 regulation of mitotic recombination
GO:0001111 RNA polymerase II promoter clearance
GO:0001113 transcription open complex formation at RNA polymerase II promoter
GO:0001174 transcriptional start site selection at RNA polymerase II promoter
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0000112 nucleotide-excision repair factor 3 complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005675 transcription factor TFIIH holo complex
GO:0005829 cytosol
GO:0097550 transcription preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5sva, PDBe:5sva, PDBj:5sva
PDBsum5sva
PubMed27610567
UniProtQ00578|RAD25_YEAST General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2 (Gene Name=SSL2)

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