Structure of PDB 5cz6 Chain Z Binding Site BS01

Receptor Information

>5cz6 Chain Z (length=222) Species: 559292 (Saccharomyces cerevisiae S288C)

QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNI
VMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGK
RFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFL
DNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGD
GLEILIVTKDGVRKEFYELKRD

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5cz6 Chain Z Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5cz6 A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): T192 V198
• Binding residue (residue number reindexed from 1): T192 V198
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.25.1: proteasome endopeptidase complex.

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0005515 protein binding

Biological Process

• GO:0010499 proteasomal ubiquitin-independent protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0000502 proteasome complex
• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005839 proteasome core complex
• GO:0019774 proteasome core complex, beta-subunit complex

External links

• PDB: RCSB:5cz6, PDBe:5cz6, PDBj:5cz6
• PDBsum: 5cz6
• PubMed: 26964885
• UniProt: P23724|PSB6_YEAST Proteasome subunit beta type-6 (Gene Name=PRE7)