Structure of PDB 1xbp Chain Z Binding Site BS01

Receptor Information
>1xbp Chain Z (length=58) Species: 1299 (Deinococcus radiodurans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKHPVPKKKTSKSKRDMRRSHHALTAPNLTECPQCHGKKLSHHICPNCGY
YDGRQVLA
Ligand information
>1xbp Chain 0 (length=2766) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaug
aaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuug
acucggggauguccgaauggggaaacccaccucguaagagguauccgcaa
ggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaa
gagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaau
ucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugaga
guccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacg
augacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugac
cgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggagggg
agugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuua
ugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccuga
cgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaau
agggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagca
ugaccagguugaaacccccgugacagggggcggaggaccgaaccggugcc
ugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccga
accuggagauagcuaguucuccccgaaauguauugagguacagccucgga
uguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacu
ccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuc
cguagccgagagggaaacaacccagaccaucagcuaaggucccuaaauga
ucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggc
uuagaagcagccacccuucaaagagugcguaauagcucacuggucgagug
acgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuaugga
uucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggag
aagccauaccggaaggagugguggagccgacugaagugcggaugccggca
ugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaagggu
uccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggc
cgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucaug
uggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuau
gcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucaca
ugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgac
ggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaa
accgacacagguguccgagugucaaugcacuaaggcgcgcgagagaaccc
ucguuaaggaacuuugcaaucucaccccguaacuucggaagaaggggucc
ccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaa
aaucacagcacucugccaacacgaacaguggacguauagggugugacgcc
ugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagc
cccggugaacggcggccguaacuauaacgguccuaagguagcgaaauucc
uugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcug
ucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccua
cccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauu
gggauucggguuucucugcguaggugggagaaacuggccggucgguggcc
acccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgu
gcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggag
gcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaa
gguagaagguggcuugacugcgagacugacacgucgagcagggaggaaac
ucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacgg
auaaaaguuaccccggggauaacaggcugaucucccccgagaguccauau
cggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcug
aagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagc
uggguucagaacgucgugagacaguucggucucuauccgcuacgggcgca
ggagaauugaggggaguugcuccuaguacgagaggaccggagugaacgga
ccgcuggucucccugcugucguaccaacggcacaugcaggguagcuaugu
ccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaaga
ugaguucucccacuguucagguaagacucccggaagaccaccggguuaag
aggccaggcgugcacgcauagcaauguguucagcggacuggugcucauca
gucgaggucuugacca
<<<<<<<<......<<<<<<<<<<<....<<<.<<<<<<<<<<<<<....
..<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>....
..>>>>>>...>>>....<<<....>>><<<<<....>>>>>.<<<....
>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........
<<....>>...<<<<......<<.....>>.....>>>>...<<<...<.
<<<<<<.<<<..<<<....<<<<......>>>>.((......<<<.....
))>>>...>>>....>>>.>>>>>>.>....<<<<<<<<<.......>>>
>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>
>>.............<<....>>....>>.........<<<<....>>>>
.............>....>>>>>>>>>>>.......<<<<<<<<<<....
...>>>>>>>>>>...<............>.<<<<<<....<<<.<<<<<
<<<<.....<...<<......>>...>.....<<....>>...<......
...>.........>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<
<<<<..<<<.....<<<<<......>>>>>......>>>...<<<..<.<
<<......>>>.>.>>>....>>>>>>>>>>..<<.......>>......
>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<
<...<<<<.<<<<<....<<<...<<<.<<<<......>>>>.>>>..>>
.>....>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.
>>>>>>>....<<<......>>>...<<<<.<<<...<<<((......<<
<<<<...........<<..<<<<<<<<.........<<<<<.<<<...<<
.........>>...>>>.........<<......>>...>>>>>.....>
>>>>>>>.>>...........))......>>>>>>.>>>...>>>>>>>.
.<.<<<<<<.....>>>>>>>.......>>>>>>..<<<<<<<.<<....
..<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><
......<<.....<<<<<<.......>>>>>><<<<....<<<<..<<..
.<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<
<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<
<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....
>>>>>>.<.<<<<.<..<<<...<<<<<.............>>>>>....
..>>>...>>>>>>.....<<<<<....>>>>>....>>>>>...>>>..
.>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>....
.<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<
<<<<<.<<.........<.....<<<<<...............>>>>><<
<<<<<<...>>>>>>>>............<<<<<<<<<..<<........
...>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<
.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>
>>>>>>..>>>>><<<<<<.......>>>>>>........<.........
..<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.
.>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..
<<<<<<<<.<<<..<......<<<<.<<<<<<..<<<<<.<<<.<<<<..
<<<<<<...<<.<<<<......<<<<<.....<<<<<<..>>>>>>..>>
>>>..>>>>.>>...>>>>>>...<<<<<<........>>>>>>.....>
>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>
>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....((
(.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>
>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>........
.....>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>
>...>>>>>>>...>>>.>.......<<<<<.<.<<<<..<<<<<<<<<.
.....>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>
>.>>....<<<<<<<....>>>.>>>>....>...>>>>>>>>>>>....
<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<
<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>
>>>....<<....<<<<.............>>>>....>>..>>>>....
...>>>>>>>..<<<..>>>....<<<<<<<<<.......>>>>>....<
<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>
>>>....>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB1xbp Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		P5 V6 P7
Binding residue
(residue number reindexed from 1)		P4 V5 P6
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1xbp, PDBe:1xbp, PDBj:1xbp
PDBsum1xbp
PubMed15554968
UniProtP49228|RL32_DEIRA Large ribosomal subunit protein bL32 (Gene Name=rpmF)

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