Structure of PDB 4w4g Chain Y4 Binding Site BS01

Receptor Information

>4w4g Chain Y4 (length=70) Species: 300852 (Thermus thermophilus HB8)

KEGIHPKLVPARIICGCGNVIETYSTKPEIYVEVCSKCHPFYTGQQRFVD
TEGRVERFQRRYGDSYRKGR

Ligand information

>4w4g Chain XA (length=1508)

guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaag
acaugcaagucgugcgggccgcggccguggucagcggcggacgggugagu
aacgcgugggugaccuacccggaagagggggacaacccggggaaacucgg
gcuaaucccccauguggacccgccccuugggguguguccaaagggcuuug
cccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaaugg
cccaccaaggcgacgacggguagccggucugagaggauggccggccacag
gggcacugagacacgggccccacuccuacgggaggcagcaguuaggaauc
uuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaag
cccuucgggguguaaacuccugaacccgggacgaaacccccgacgagggg
acugacgguaccgggguaauagcgccggccaacuccgugccagcagccgc
gguaauacggagggcgcgagcguuacccggauucacugggcguaaagggc
guguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugg
gggagcgugggauacgcucaggcuagacggugggagagggugguggaauu
cccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcga
aggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggag
caaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcua
ggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccu
ggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgc
acaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuac
caggccuugacaugcuagggaacccgggugaaagccuggggugccccgcg
aggggagcccuagcacaggugcugcauggccgucgucagcucgugccgug
agguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugcc
agcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaa
ggaggggacgacgucuggucagcauggcccuuacggccugggcgacacac
gugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaa
ucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccau
gaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacg
uucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuac
ccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugac
uggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca
ccuccuuu

......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<
<<.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<....
...<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>
>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>
>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......
>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<
<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>......
..<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<
<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>
..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>
.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<
<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>
....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<
<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<..
..>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<
<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..
<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.
<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.
<<.<<<<<<..<<<<<<<<<<......<<........>>..........<
<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<.....
...>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<...
.>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<.
..<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>.....
...>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>
>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>...
.>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>.
...>.....>>>>>>....<<<<<<<..........>>>>>>>......>
>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<
<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>
>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......
........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4w4g Defining the mRNA recognition signature of a bacterial toxin protein.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): R58 F59
• Binding residue (residue number reindexed from 1): R57 F58

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4w4g, PDBe:4w4g, PDBj:4w4g
• PDBsum: 4w4g
• PubMed: 26508639
• UniProt: Q5SJE1|RL31_THET8 Large ribosomal subunit protein bL31 (Gene Name=rpmE)