Structure of PDB 7pwo Chain Y2 Binding Site BS01

Receptor Information
>7pwo Chain Y2 (length=133) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLNSAVTASRRKCRKAYFTANAETRAKMMSSRLSKELRAEHKIKTMPIR
RGDIVEIFTGGHKGTGKVVEVRRRDYKICVEGINQKARNPEAKPVPYPIH
PSNCIIKELYMNGSRYRAIKRRQERNAERLARI
Ligand information
>7pwo Chain 1 (length=2448) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cggcccgaggcggcgggggcgacgggcggaacuuaagcauaucaguacgc
cccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcggga
ggagcccgccccgaaggcgcgcugugggcgccgcgagggggcccgagggc
cccgcccgagagggugcaagccccguacggcgggcgaguagcgcugcuug
agcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgcccc
gggaccgauagcggaccaaguagcgcgagcgaacggugaaaaggacgccc
ggccgcucaaaagaccugaacccggccggcgccggcccgccggccccguc
ucgaaacacggaccgaggagccacgcgccgcggcgagcccgagggccccg
cggcggagcgagcgcgagacgccccgggcccgccgcgccccugcgggcgu
gcgcgggccgagccgcggcgcgugggcccgaaaggcggugaucuaugccc
ggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcug
acgcgcagaucgcucgucggagccgggcaugggggcgaaagacucaucga
accgccugguagcugguugccuccgaaaugucucccaggacagccgccgc
ccgcaguugcggcccguagagcgcuggccggcggccgccccccaaacucc
gaagggccgcgccgccccgcccuggccugggcggggcgggcgaaugcggg
cggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgaucc
ggacgccgggccagggugcgccgccggggccggaacggcgucggccgcgg
ccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgc
cgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgc
gcaggccccgccggaccggccucuggugcagaucucggcagcaguagcgc
uacuccgcccccggaggacugagggggagacggguuccgcggcgccugca
ucuggccgcgggugacucgggccuaagcggcgggugaagaccgggaaggg
gcgugcccgcccgucgaacggggagccggcggagacuccggcaggcgcgg
gcggagacgcgccccccggcgacgcgcacggggaccgcggcgggcggcgc
cccggcccgcgaacgccccgcagcccccggacgccuugcgcggagagggg
ggcccgggggcggaccgcgcguccccggccgccccugaaaagccgggggg
cccgcgcgccguaccgaccgcacaggacuccggggucagcagccucuagc
gcgggagcgaacgcggcucagggaagucggcaagccggcuccguaaccuc
gggaaaaggaguggcucugacggggucagaacuggaacggacgcggggau
cccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcug
gcgcgacgugauuucugcccagugccagaccgucaccgugaagcgauccg
ccgaagcccugguaaacggcgggaguaaugacucucuuaagguagccaaa
ugccucgucgggcaauuuccgacggcaugaauggaccaacgaggauccca
cugucccgagccgcgccuccgcgagccuccagccucgggaacgggcgagg
gccggccagcggggcaagaagacccuuuugagcuugacuccagcccgggc
cuguggggcggggccgccccgcucacccggucgcgcggggacccgcccgg
gcggggaguucggcuggggcggcgcgccugcuacaccggaccgcaggcgu
cccacggcgggcucagcgaggacccucccgcggagcagaagggcacaagc
ccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggccu
accgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguua
ccacagggauaacuggcuuguggccgccgagcgcccgcagcgacgcggcu
uuuugauccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcg
gaagcgucggauuguucacccguucaagggaucgugagcuggguuuagac
cgucgugagacgguuaguuuuacccuacuggccccggggccagagcacgg
cgggccaguacggaggaacgcccgccgcgggcgcccagccccgcgguugc
ccgccggggcagaccgcgcgcccgggcccgggggccuggcgcugccgccu
cuaaagcgccaccccccccuccggccccgccgcccgcgccccagccccgu
gcccccugcccgaggcggcccccgcccgggaggaccacccggcgcggcgc
cccuguacggcgagggcgcguucgcccggggggcgcgccgcaggcgcg
......................<<<<<<.....<......>......>>>
>>.>.........<<....>>..<<<<<....<<.....>>.....>>>>
>..[[[...<<<<...........>>>><<<<..<..<<<<<......>>
>>>((......<<<.....))>>>...>>>>>........<<<<<<<...
.....>>>>>>>...(((((..<<<<<<)))))..]]]............
......................<<....>>................<<<.
>>>...........................<<<<<<..>>>>>>.<<<<.
.......>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<.>>>.
.>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>
>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<
<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<
<........>>>>.>>>....>>>>>>>>>...<<.......>>......
>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<
<<<<<.<<<<<<<<<...<<<...<<<..<<<<..>>>>..>>>..>>.>
...>>>>>>>.<<<<<<<<<<<......>>>>>>>>>>>...>>>>>>>>
>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>
>...<<<<<<<..<<<<(((...<<<<<<<.....<<<.<<<<<<<..>>
>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<
<<<..>>>>>>....>>>>>><.<<<<<<<<...<<......<<<<<.<<
....>>.>>>>>...>>>>>>>>>>..>.....>>>>>.<<.....<<..
..<<<<<....>>>>>..<<.....<<<<..<<...<<<<<<...<....
...>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<<
<<..>>>>...>>.>....>>...<<<<<........>>>>>))<<<<<<
<<<....>>><<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<.....
....>>>>>....<<<<<<...<<<<<<....<<.....>>......>>>
>>>...>>>>>>..>>>>>.>>>>>>>..>>>.........>>>>>>>>>
>>>>>>>.>>>..>>..<<.....>>.>>>>.<<<<.....>>>>..>>.
...<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..
>>.....>>>>><<.<<<<<<...>>>>>>.>>............<<<<<
<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>....
..>>>>>>>...<<..<<<..<<<<<<<...<<....<<<.<....>.>>
>....>>.>>>>>..>>>>><<<<<<....>>>>>>........<.....
......<<<<<<.....>>>>>>....>.....>>....>>.>>>>>>>.
.>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>
...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<<
..<<<<<<<<<..>>>>>>>>>...<<<<......>>>>.....>>>>>>
>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..
<<...<<<<<<<...<.<<<<..>>>>.>.....<<...(((>>....>>
>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>)))
.......((((((.((((.>>>>>>))))))))))..........]]]].
.}}.}}}.......<<.<.<.<<<<<<...<<.......>>...>>>>>>
...>>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>
>..>>>.<<<.........>>>....>>>>>..>...>>>.>>....<<<
<<<<....>>>>>>>........}}}.))))))..<<<<<<.<<<..<<<
<<<<<..............>>>>>>>><<<<<...<.<....<<<<<<<<
<<....>>>>>.>>>>>....>.>.>>>>>.<<<...<<<<<<.......
....>>>>>>...>>>..>>>.>>>>>>...<.<<<..............
...............>>>.>...<<.<<<<.......>>>>..<<<<<<<
<<<<....<<<<<<.<..>.>>>>>>...>>>>.>>>>>>>....>>.
Receptor-Ligand Complex Structure
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PDB7pwo Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		M1 K2 L3 N4 T8 R11 K13 R15 R33 R39 K45 T46 T59 G60 G61 Q85 R88 Y97 P98 H100 S102 N103 R125 R129 R132
Binding residue
(residue number reindexed from 1)		M1 K2 L3 N4 T8 R11 K13 R15 R33 R39 K45 T46 T59 G60 G61 Q85 R88 Y97 P98 H100 S102 N103 R125 R129 R132
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pwo, PDBe:7pwo, PDBj:7pwo
PDBsum7pwo
PubMed35100413
UniProtA8BFT3

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