Structure of PDB 8rhl Chain Y Binding Site BS01

Receptor Information

>8rhl Chain Y (length=212) Species: 4932 (Saccharomyces cerevisiae)

TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAA
DCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTM
ICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSV
EDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV
KEEEGSFNNVIG

Ligand information

>8rhl Chain h (length=4) Species: 32630 (synthetic construct)

FLYG

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8rhl Macrocyclic Oxindole Peptide Epoxyketones-A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): T1 A20 T21 A27 G47 Y170
• Binding residue (residue number reindexed from 1): T1 A20 T21 A27 G47 Y170

Enzymatic activity

• Enzyme Commision number: 3.4.25.1: proteasome endopeptidase complex.

Gene Ontology

Molecular Function

• GO:0004298 threonine-type endopeptidase activity

Biological Process

• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0005839 proteasome core complex

External links

• PDB: RCSB:8rhl, PDBe:8rhl, PDBj:8rhl
• PDBsum: 8rhl
• PubMed: 38628795
• UniProt: P30656|PSB5_YEAST Proteasome subunit beta type-5 (Gene Name=PRE2)