Structure of PDB 8rch Chain Y Binding Site BS01

Receptor Information

>8rch Chain Y (length=1044) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLN
VGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRA
RYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVF
NKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQEL
EVSMKNCIQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKC
VSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLF
QKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWD
LAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQL
PIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSS
ARELRPLLVFIWAKILAVDSSCQADLVKDNGHKYFLSVLADPYMPAEHRT
MTAFILAVIVNSYHTGQEACLQGNLIAICLEQLNDPHPLLRQWVAICLGR
IWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALGTFVGNSAER
TDHSTTIDHNVAMMLAQLVSDGSPMVRKELVVALSHLVVQYESNFCTVAL
QFISVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIAYKGFCDWSARYFAQ
PVMKIPEEHDLESQIRKEREWRFLRNSRVRRQAQQVIQKGITRLDDQIFL
NRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTR
VTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSAGM
VVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSH
RSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHI
VSVSVNGDVRIFDPRMPESVNVLQIVKGLTALDIHPQADLIACGSVNQFT
AIYNSSGELINNIKYAISCLAFHPHWPHLAVGSNDYYISVYSVE

Ligand information

>8rch Chain X (length=8) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ESQFEMDI

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8rch cryoEM structure of mTORC1 with the cancer-associated 1455-EWED-1458 duplication variant, overall refinement
Resolution	4.0 Å
Binding residue (original residue number in PDB)	R338 L441 R446 Y475 K478 L479 S482
Binding residue (residue number reindexed from 1)	R305 L408 R413 Y442 K445 L446 S449

External links

PDB	RCSB:8rch, PDBe:8rch, PDBj:8rch
PDBsum	8rch
PubMed
UniProt	Q8N122\|RPTOR_HUMAN Regulatory-associated protein of mTOR (Gene Name=RPTOR)

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