Structure of PDB 8i0r Chain Y Binding Site BS01

Receptor Information
>8i0r Chain Y (length=118) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNPLTKVKLINELNEREVQLGVADKVSWHSEYKDSAWIFLGGLPYELTEG
DIICVFSQYGEIVNINLVRDKKTGKSKGFCFLCYEDQRSTILAVDNFNGI
KIKGRTIRVDHVSNYRAP
Ligand information
>8i0r Chain G (length=71) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cggccuccgaacgguaagagccuagcauguagaacugaugaugucauacu
uauccugucccuuuuuuuucc
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Receptor-Ligand Complex Structure
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PDB8i0r Molecular Basis for the activation of Human spliceosome
Resolution3.0 Å
Binding residue
(original residue number in PDB)		M1 N2 P3 L4 T5 K8 F39 F79 F81 R105 R116 A117 P118
Binding residue
(residue number reindexed from 1)		M1 N2 P3 L4 T5 K8 F39 F79 F81 R105 R116 A117 P118
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005686 U2 snRNP
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0031965 nuclear membrane
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome

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Biological Process
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Cellular Component
External links
PDB RCSB:8i0r, PDBe:8i0r, PDBj:8i0r
PDBsum8i0r
PubMed39068178
UniProtQ9Y388|RBMX2_HUMAN RNA-binding motif protein, X-linked 2 (Gene Name=RBMX2)

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