Structure of PDB 7wtt Chain Y Binding Site BS01

Receptor Information
>7wtt Chain Y (length=124) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTP
DVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKT
SRKQRKERKNRMKKVRGTAKANVG
Ligand information
>7wtt Chain 2 (length=1575) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccaauuccagcuc
caauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucu
cucucggccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggc
cgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuu
uguugguuuucggaacugaggccaugauuaagagggacggccgggggcau
ucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggacc
agagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaaguc
ggagguucgaagacgauaccgucguaguuccgaccauaaacgaugccgac
cggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaa
accaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuua
aaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuu
gcacccggcccggacacggacaggauugacagauugauagcucuuucucg
auuccgugggugguggugcauggccguuguuggcugguuaauuccgauga
acgagacucuggcaugcuauucuuagagggacaaguggcguucagccacc
cgagauugagcuaacaggucugugaugcccuguccggggcugcacgcgcg
cuacacugacuggcucagcguguccuacgccggcaggcgcggguaacccg
uugaaccccauucgugauggggaucggggauugcaauuauuccccaugaa
cgaggaauucccaguaagugcgggucauaagcuugcguugauuaaguccc
ugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagug
aggcccucggaucggccccgccggggugcccuggcggagcgcugagaaga
cggucgaacuugacuaucuagaggaaguaaaagucgagguuuccguaggu
gaaccugcggaaggaucauuaacgg
...<<<<<.[[((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<..........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<.......
....>..>>.........<<<<<........<<<<........>>>>.>>
>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<...
<<.<<<..>>>>>...<<<<<<.........<<...<.......>.<<<<
.>>>>...>>........>>>..>>>........<.<<.<<<<<<<....
...........>>>>>>>.>>.>....>>....<<<<<<..<...<<<<.
.<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>....
...<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<
<<<<...<...<<<<....>>>>...>>>>>>>>..........<<<.<<
.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..)
)>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>.
.)))).]]....<<<<<<<<..<<..<<<<<.<<<<.<<<<<<.......
...<<<<<....<.<<<<<<.......<<.<<<........>>>.>>...
..>>>>>>..>...<<<.<<.<<<<<<.<<<...<<<......>>>...>
>>....<<<...<...<<<....>>>..>.....<<<<<.....>>>>>.
.......>>>...>>.>>>>..>>..>>>....>>>>>...>>.>>>>.>
>>.>...<<.<<<........<.<<<.<<<<....>>>>.>>>....>..
.......>>>.>>......<.....<<<<<..........>>>>>.....
>.....>>>>>.....<<<<<<<<<.....>>>>>>>>>......>>...
>>>>>>>>......<<<...<<....<<<<.<<....<<<<<<<<.<<<.
.<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>
.>>>>..>>>.>>>>>>>>...>>.>>>>.....>>.>>><<<<<<<<<.
...>>>>>>>>>.............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wtt The nucleoplasmic phase of pre-40S formation prior to nuclear export.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R10 K11 F12 T14 K32 A33 T34 P36 K37 G59 F60 R61 T62 H63 F64 G66 H89 R93 R104 K105 R107 K108 E109 K111 N112 K115 R118 G119 T120
Binding residue
(residue number reindexed from 1)		R8 K9 F10 T12 K30 A31 T32 P34 K35 G57 F58 R59 T60 H61 F62 G64 H87 R91 R102 K103 R105 K106 E107 K109 N110 K113 R116 G117 T118
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0031369 translation initiation factor binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0034101 erythrocyte homeostasis
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0044391 ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7wtt, PDBe:7wtt, PDBj:7wtt
PDBsum7wtt
PubMed36321656
UniProtP62847|RS24_HUMAN Small ribosomal subunit protein eS24 (Gene Name=RPS24)

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