Structure of PDB 7ttu Chain Y Binding Site BS01

Receptor Information
>7ttu Chain Y (length=136) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLLPKRVKYRRQHRPKTTGRSKGGNYVTFGEFGLQATTTSWITSRQIESA
RIAMTRYMKRGGKVWIKIFPHTPYTKKPLEVRMGAGKGAVEGWIAVVKPG
RILFEVAGVSEEVAREALRLASHKLPVKTKFVKREE
Ligand information
>7ttu Chain 1 (length=2684) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaa
ggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugau
ccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucg
auaugugaauacauagcauaucagaaggcacacccggagaacugaaacau
cuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcg
agcgaaacgggaagagcccaaaccaacguugggguuguaggacacucuag
uuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaag
guaauaauccuguagucgaaaauguugucucucuugaguggauccugagu
acgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaa
ggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaag
gugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcu
uacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaau
gaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagcc
guagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccg
aaaccaggugaucuacccuuggucagguugaaguucagguaacacugaau
ggaggaccgaaccgacuuacguugaaaagugagcggaugaacugagggua
gcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauag
cuuuagggcuagccucaagugaugauuauuggagguagagcacuguuugg
acgagcgaauucagacaaacuccgaaugccaauuaauuuaacuugggagu
cagaacaugggugauaagguccguguucgaaagggaaacagcccagacca
ccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugc
cacagagugacacugcgccgaaaauguaccggggcuaaacauauuaccga
agcuguggauugucgacaaugguaggagagcguucuaagggcguugaagc
augaucguaaggacauguggagcgcuuagaagugagaaugccggugugag
uagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccag
aggaaggcucguccgcucuggguuagucggguccuaagcugaggccgaca
ggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucgu
aucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcac
gucuaagcaguaaggcgcugagcugugauggggagaagaccuucgagucg
uugauuucacacugccgagaaaagccucuagauagaaaauaggugcccgu
accgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagc
gaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaag
gggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaa
gcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugaugua
uaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcu
ucugcgaagcuacgaaucgaagccccaguaaacggcggccguaacuauaa
cgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacga
aaggcguaacgauuugggcacugucucaacgagagacucggugaaaucau
aguaccugugaagaugcagguuacccgcgacaggacggaaagaccccgug
gagcuuuacuguagccugauauugaaauucggcuuucuaacccgcaccac
uuaucguggugggagacagugucaggcgggcaguuugacuggggcggucg
ccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguugga
aaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuac
aagucgagcagggucgaaagacggacuuagugauccggugguuccgcaug
gaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuua
ucucccccaagaguucacaucgacggggagguuuggcaccucgaugucgg
cucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcc
cauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggu
cccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacg
agaggaccgggauggacauaccucugguguaccaguugucgugccaacgg
cauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaag
caugaagccccccucaagaugagauuucccaacuucgguuauaagauccc
ucaaagaugaugagguuaauagguucgagguggaagcauggugacaugug
gagcugacgaauacuaaucgaucgaagacuuaau
<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......
<<<<<<.[...((.>>>.....<<<<<<<..<<.))...]..>>.....>
>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<
<<<<<<.........>>>>>>>.>>.>>....<<<<<......<<....>
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<..>>>>......<<<<<.......
........<.<<<<<<<.<<<...<<<<<......>>>>>((......<<
<.....))>>>...>>>...>>>>>>>..>.........>..>>>>....
.<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..
)))......]].>>>>>>>.]]...............<<....>>....]
].........<<<<....>>>>.............}....>>>>>>>>>>
>.......<<<<..<<<<......>>>>..>>>>...<.<........>.
>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>
...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<
...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>
.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<
<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<
<........>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>
..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<
<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<.<<.
.......>>.>.>>>>.>>...........))).....>>>>>>.>>>..
.>>>>>>><<<<<..>>>>>....>>>>>><.<<<<<<<.<<......<<
<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><....
..<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<
<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....
>>>...>>>...>>...<<<<<........>>>>>))<<<<<<.......
.<<...<<<<....<<<<...<<...<......<<<.........>>>..
.<....<<<<...<<..>>...>>>>.....>..................
.>....>>...>>>>.........>>>>..>>.......>>>>>>>>>>.
.>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<.
...<<<<<<<<.<<...............<<<<<....<<..>>.....>
>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<
<<<..<<<.........>>>..<<<<<<<.....<<......>>......
.>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<.
...>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>
>>>>>........<...........<<<<<<.....>>>>>>.....>..
..>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>.....>..
...<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[
[<<<<..<<<<<.<<<<<<<<..<<<<......>>>>....<<.<<<<<<
.....>>>>>>>>......>>>>>>>>..>>>>>..<<<<.....>>>><
<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.....
..>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<....
..>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>
>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<
.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<
<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>
>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>...
.]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.......
........>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<....>>>>
>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>
>>>....>>>.>>>>.......>>>>>>>.<<<....>>>....<<<<<<
<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>.
..>>>..>>>>>.>>>...>>>>....>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7ttu A Structurally Characterized Staphylococcus aureus Evolutionary Escape Route from Treatment with the Antibiotic Linezolid.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		P4 K5 R6 Y9 R11 H13 R14 K16 K22 G24 F29 W41 R45 Q46 S49 R56 F69 H71 K77 E80 V81 R82 M83 G84 A85 G86 K87 R101 H123 K124 P126 K128 K130
Binding residue
(residue number reindexed from 1)		P4 K5 R6 Y9 R11 H13 R14 K16 K22 G24 F29 W41 R45 Q46 S49 R56 F69 H71 K77 E80 V81 R82 M83 G84 A85 G86 K87 R101 H123 K124 P126 K128 K130
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ttu, PDBe:7ttu, PDBj:7ttu
PDBsum7ttu
PubMed35736238
UniProtQ2FW13|RL16_STAA8 Large ribosomal subunit protein uL16 (Gene Name=rplP)

[Back to BioLiP]