Structure of PDB 7qh7 Chain Y Binding Site BS01

Receptor Information

>7qh7 Chain Y (length=175) Species: 9606 (Homo sapiens)

GLEEFFDDPKNWGQEKVKSGAAWTCQQLRNKSNEDLHKLWYVLLKERNML
LTLEQEAKRQRLPMPSPERLDKVVDSMDALDKVVQEREDALRLLQTGQER
ARPGAWRRDIFGRIIWHKFKQWVIPWHLNKRYNRKRFFALPYVDHFLRLE
REKRARIKARKENLERKKAKILLKK

Ligand information

>7qh7 Chain A (length=1256)

gcuaaaccuagccccaaacccccaccuuacuaccacaacuuagccaaacc
auuuacauaaaguauaggcgauagaaauugauggcgcaauagauauagua
ccgcaagggaaagacaagcauaauauagcaaggacuaaccccuauaccuu
cugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaa
gacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacaccc
gucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccu
accgagccuggugauagcugguuguccaagauagaaucuuaguucaacuu
uaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuagucca
aagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaa
aaaaugaucccaaacauauaacugaacuccucacacccaauuggaccaau
cuaucauauagaagaacuaauguuaguauaaguaacaugaaaacauucuc
cuccgcauaagccugcgucagaucugacaauuaacagcccaauaucuaca
aucaaccaacaaguuauuacccucacugucaacccaaccaggcaugcuca
uaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgcc
uguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgcc
uccuuaaauaggcuccacgaggguucagcugucucuuacuuuuaaccagu
gaaauugaccugcccgugaggcgggcauaacacagcaagacgaagacccu
auggagcuuuaauuuauuaaugcaaaaccugcauuaaaaauuucgguugg
ggcgaccucggagcagaacccaaccuccgaggcuaagacuucaccaguca
aagcgaagauccaauaacuugaccaacggaacaaguuacccuagggcaau
ccuauucuagaguccauaucaacaauaggguuuacuggaucaggacaucc
cgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccu
cgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuu
auuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagc
gccuucuaaaugauaucaucucaacuuaauacccacacccacccaagaac
aggguu

<<<.......<<<<...............................<....
..>.....<.....<<.....>>....>....>>.>>.............
<<....>>........>>>...........<<<.......>>>...<.<<
......>>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>
>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<
..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>.
.....>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<
<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<
<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...
<.....................>...>>>>>>........>>>>>>...<
<<<<...>>>>>.........>>>>>><......<<..<<<....>>><<
<<..<<<<........<<<<<..>>>>>......<<<...<<<<......
..............>>>>.......>>>.....<<.....>>.>>>>...
..>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..
<<<.........>>>...<<<<<<.............>>>>>>.......
.<<<.....>>>.....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>
.....>.....<<<<<.....>>>>>.......<<..<<<.<<...<<<<
<.<<<<<<..<<<<..<<<<<<<<.....>>>>>>>.>>>>>..<<<<..
...>>>><<<<<<...........>>>>>>.<<<..<<<<.....>>>>.
.>>>.......<<<....>>>............>>>>..>>>>>>>...<
<<<<<<...<<.......>>...>>>>>>>.....<<<<..<<<<<..<<
.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>
.....>>>>......<<<<<<<....>>>.>>>>....>>..>>>.>>..
<<<.<<<.................>>>.>>><<<<<...<<<....>>>.
>>>>>.<<<................>>>............<<<<......
.>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qh7 A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
• Resolution: 2.89 Å
• Binding residue (original residue number in PDB): K120 R121 R123 R164 K180 K182 W184 V185 I186 R193 R196 R198 R213 R216 R222 N225 L226 K229 K230
• Binding residue (residue number reindexed from 1): K58 R59 R61 R102 K118 K120 W122 V123 I124 R131 R134 R136 R151 R154 R160 N163 L164 K167 K168

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005761 mitochondrial ribosome

External links

• PDB: RCSB:7qh7, PDBe:7qh7, PDBj:7qh7
• PDBsum: 7qh7
• PubMed: 35177605
• UniProt: Q9HD33|RM47_HUMAN Large ribosomal subunit protein uL29m (Gene Name=MRPL47)