Structure of PDB 7ohr Chain Y Binding Site BS01

Receptor Information

>7ohr Chain Y (length=126) Species: 559292 (Saccharomyces cerevisiae S288C)

AKQSLDVSSDRRKARKAYFTAPSSQRRVLLSAPLSKELRAQYGIKALPIR
RDDEVLVVRGSKKGQEGKISSVYRLKFAVQVDKVTKEKVNGASVPINLHP
SKLVITKLHLDKDRKALIQRKGGKLE

Ligand information

>7ohr Chain 1 (length=2373)

guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaau
aagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaa
gcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguugua
auuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaac
aggacgucauagagggugagaaucccguguggcgaggagugcgguucuuu
guaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugg
gugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaagu
acagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacg
ugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguu
uugguggcaggauaaauccauaggaauguagcuugccucgguaaguauua
uagccugugggaauacugccagcugggacugaggacugcgacguaaguca
aggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaa
ggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaau
gaacgagguuggggccucgcaagaggugcacaaucgaccgauccugagga
uggauuugguaagagcauagcuguugggacccgaaagauggugaacuaug
ccugaauagggugaagccagaggaaacucugguggagcucgguucgacgu
ucgaucgugaauuggguauagggcgaaagacaaccaucuaguagcugguu
ccugccgaaguuucccuaggauagcagaagcucguaucaguuuuaugagu
aagaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgau
gcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucag
acacaaaagguguuaguucaucuagacagccggacgguggccauggaagu
cggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcc
cugaaaauggauggcgcucaagcguguuaccuauacucuaccgucagggu
ugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagcc
uagaccguaaggucgggucgaacggccucuagugcagaucuuggugguag
uagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguucc
acgucaacagcaguuggacguggguuagucgauccuaagagauggggaag
cuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaaucc
gguuaagauuccggaaccuggauauggauucuucacgguaacguaacuga
auguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaa
cagcuuaucaccccggaauugguuuauccggagauggggucuuauggcug
gaagaggccagcacugcuggcuccggugcgcuugugacggccgugaaaau
ccacaggaaggaauaguuuucaugccaggucguacugggucuccaaggug
aacagccucuaguugauagaauaauguagauaagggaagucggcuguccc
uaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaauc
agcggggacccuguugagcuugacucuaguuugacauuauugucaggugg
ggaguaaaguuaccacagggauaauggcuuguggcagucaagcguucagc
gacauugcucggcucuuccuaucauaccgaagcagaauucgguaagcguu
ggauuguucacccacuaauagggaacguggcuggguagaccgucgugaga
cgguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuu
aguacgagaggaacaguucauucggauaauugguuuuugcggcugucuga
ucaggcaugccgcgaagcuaccauccgcuggauuauggcugaacgccucu
aagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauau
agauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggc
uagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauug
caaugucauuuugcguggggauaaaucauuuguauacgacuuagauguac
aacgggguauuguaagcaguagaguagccuugguuacgaucugcugagau
uaagccuuuguugucugauuugu

..........................<<<<<<.....<......>.....
.>>>>>.>...<.....<<....>>..<<<<<......<<.....>>...
..>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>......
..>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......
>>>>.((......<<<.....))>>>....>>>>>>>>>..>>>>>>>..
..>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<
<<<<..>>>>>>..>>>....>............................
.<<....>>...............<<<<....>>>>..............
....................<<<<<.<<<<<......<<<<<<<.<<<<<
<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>....
...>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.
....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<
<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>.....
......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<......
.>>>.>>>>>....>>>>>>.>>>>>>..<<.<..<<<<<<<...<<<<<
<<<<....<<<<...<<<<<<<....>>>>>>>...>>>>...<<<....
.>>>........>>>>>>>>>...........>>>>>>>.....>.>>..
<<<<<<....<...........><<<<<<<<<....<<<.<<<<<<..>>
>>.>>>>>..>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...
.<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<
.......<<<.<<<<<<<<<<.......<<<<<.<<<...<<........
.>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>
>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<
.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<
<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<...
..<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<
<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<...
.>>>........<<<<<<........>>>>>>....>>....>>...<<<
<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<..
.<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..(((..>>>>>><...
<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>
....><<<<<<<...>>>>>>>>>>>...>>>>>>>.>>>>........>
>>>>>...>......>.>>.>>>>>>>>>>>>..>>...>>>>>.<<<<.
....>>>>..>>>>..<<<<.....<<<<<<<.<<............>>.
>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<
<<..<<..<<<<<.<..<<<<..<<<<.<<<<<<<<....>>>>>>>>..
>>>>..>>>>....>>>>>>............<<<<<....<<.....>>
....>>>>>.<<...<<<<<..<.<<<<<<<......>>>>>>>...>.<
<<.........>>>.....>>>>>......>>.....<<<<<<<....>>
>>>>>.........>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<.
..............>>>>>>.><<<<<...<<<<...<<<<<<.<<<<))
).>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<..........
.>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<
....<<..........<<<<<<.....>>>>>>......>>.......<<
<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>......
.......>>.>>>.>>>>>>..<<<<<.<.............>.....<<
<<<.<<<.<<<....<<<<....<..<<<..>>>..>...>>>>...>>>
....>>>..>>>>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ohr Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors.
• Resolution: 4.72 Å
• Binding residue (original residue number in PDB): A2 K3 Q4 S5 L6 V8 S9 S10 R12 A15 Y19 V29 L30 S32 P34 K46 R60 G61 S62 K87 K89 V90 N91 N98 S102 K103 R121 K122
• Binding residue (residue number reindexed from 1): A1 K2 Q3 S4 L5 V7 S8 S9 R11 A14 Y18 V28 L29 S31 P33 K45 R59 G60 S61 K86 K88 V89 N90 N97 S101 K102 R120 K121

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042273 ribosomal large subunit biogenesis

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:0032991 protein-containing complex
• GO:0043232 intracellular non-membrane-bounded organelle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ohr, PDBe:7ohr, PDBj:7ohr
• PDBsum: 7ohr
• PubMed: 34813592
• UniProt: P05743|RL26A_YEAST Large ribosomal subunit protein uL24A (Gene Name=RPL26A)