Structure of PDB 7o2l Chain Y Binding Site BS01

Receptor Information

>7o2l Chain Y (length=212) Species: 4932 (Saccharomyces cerevisiae)

TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAA
DCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTM
ICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSV
EDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV
KEEEGSFNNVIG

Ligand information

• Ligand ID: V08
• InChI: InChI=1S/C7H12O4/c1-4(2)5(3-8)6(9)7(10)11/h3-6,9H,1-2H3,(H,10,11)/t5-,6+/m0/s1
• InChIKey: YIJPJSMEWHRJCU-NTSWFWBYSA-N
• SMILES:
  OpenEye OEToolkits 2.0.7: CC(C)C(C=O)C(C(=O)O)O
  OpenEye OEToolkits 2.0.7: CC(C)[C@H](C=O)[C@H](C(=O)O)O
  CACTVS 3.385: CC(C)[CH](C=O)[CH](O)C(O)=O
  CACTVS 3.385: CC(C)[C@H](C=O)[C@@H](O)C(O)=O
• Formula: C7 H12 O4
• Name: (2 {R},3 {S})-3-methanoyl-4-methyl-2-hydroxy-pentanoic acid
• PDB chain: 7o2l Chain Y Residue 901

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7o2l Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): T1 A20 G47
• Binding residue (residue number reindexed from 1): T1 A20 G47
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.4.25.1: proteasome endopeptidase complex.

Gene Ontology

Molecular Function

• GO:0004298 threonine-type endopeptidase activity

Biological Process

• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0005839 proteasome core complex

External links

• PDB: RCSB:7o2l, PDBe:7o2l, PDBj:7o2l
• PDBsum: 7o2l
• PubMed: 35469007
• UniProt: P30656|PSB5_YEAST Proteasome subunit beta type-5 (Gene Name=PRE2)