Structure of PDB 6zmt Chain Y Binding Site BS01

Receptor Information
>6zmt Chain Y (length=124) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTP
DVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKT
SRKQRKERKNRMKKVRGTAKANVG
Ligand information
>6zmt Chain 2 (length=1569) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucucucucggccgaagcguuuacuuugaaaaaauuagagug
uucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggacc
gcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggac
ggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggc
gcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaauca
agaacgaaagucaccauaaacgaugccgaccggcgaugcggcggcguuau
ucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccg
gggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggca
ccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccuc
acccggcccggacacggacaggauugacagauugauagcucuuucucgau
uccgugggugguggugcauggccguucuuaguugguggagcgauuugucu
gguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcga
ccggucggcguaacuucuuagagggacaaguggcguucagccacccgaga
uugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcg
cgcuacacugacuggcucagcguguccuacgccggcaggcgcggguaacc
cguugaaccccauucgugauggggaucggggauugcaauuauuccccaug
aacgaggaauucccaguaagugcgggucauaagcuugcguugauuaaguc
ccugcccuuuguacacuacuaccgauuggaugguuuagugaggcccucgg
aucggccccgccggggugcccuggcggagcgcugagaagacggucgaacu
ugacuaucuagaggaagua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<....<<.<<<....>>>..>>.....>>>......<<..<.......
....>..>>.........<<<<<((......<<<<.....<<..))>>..
.....>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<...<<.<<<..>>>>>...<<<<<<.<.......<<...<.
......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<
.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<
<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>
>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>..
.>>.>....<<.>>..........<<<.<<.<<<..<.<<<<<<.<<<<<
....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>
.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<
..<<..<<<<<..<<<.<<<<<<......<<........>>.........
.<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....
>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<
<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<
<..>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>......
..>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>
.>>>.....<<.<<<........<.<<<.<<<<....>>>>.>>>....>
.........>>>.>>......<.....<<<<<..........>>>>>...
..>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>.
..>>>>>>>>>>.>>.<<<<.<<....<<<<<<<<.<<<..<<<<.<<..
.<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>
.>>>>>>>>...>>.>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zmt Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R10 K11 F12 G31 K32 A33 T34 P36 K37 G59 F60 T62 H63 F64 G66 H89 R93 R104 K105 K108 E109 K111 N112 K115 G119 T120
Binding residue
(residue number reindexed from 1)		R8 K9 F10 G29 K30 A31 T32 P34 K35 G57 F58 T60 H61 F62 G64 H87 R91 R102 K103 K106 E107 K109 N110 K113 G117 T118
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0031369 translation initiation factor binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0034101 erythrocyte homeostasis
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0044391 ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6zmt, PDBe:6zmt, PDBj:6zmt
PDBsum6zmt
PubMed32680882
UniProtP62847|RS24_HUMAN Small ribosomal subunit protein eS24 (Gene Name=RPS24)

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