Structure of PDB 6z9t Chain Y Binding Site BS01

Receptor Information
>6z9t Chain Y (length=1343) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPV
KDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPTAHIW
FLKSLPSRIGLLLDMPLRDIERVLYFESYVVIEGGMTNLERQQILTEEQY
LDALEEFGDEFDAKMGAEAIQALLKSMDLEQECEQLREELNETNSETKRK
KLTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLLNDLYRRVINRNNRLK
RLLDLAAPDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSLADM
IKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPF
IYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLH
RLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEA
RALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDCVNAKGEGMVLTGP
KEAERLYRSGLASLHARVKVRITEYEKDANGELVAKTSLKDTTVGRAILW
MIVPKGLPYSIVNQALGKKAISKMLNTCYRILGLKPTVIFADQIMYTGFA
YAARSGASVGIDDMVIPEKKHEIISEAEAEVAEIQEQFQSGLVTAGERYN
KVIDIWAAANDRVSKAMMDNLQTETVINRDGQEEKQVSFNSIYMMADSGA
RGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGAR
KGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTHEGIMMTPVIEGGD
VKEPLRDRVLGRVTAEDVLKPGTADILVPRNTLLHEQWCDLLEENSVDAV
KVRSVVSCDTDFGVCAHCYGRDLARGHIINKGEAIGVIAAQSIGEPGTQL
TMRTFHIGGAASRAAAESSIQVKNKGSIKLSNVKSVVNSSGKLVITSRNT
ELKLIDEFGRTKESYKVPYGAVLAKGDGEQVAGGETVANWDPHTMPVITE
VSGFVRFTDMIDGQTITRQTDELTGLSSLVVLDSAERTAGGKDLRPALKI
VDAQGNDVLIPGTDMPAQYFLPGKAIVQLEDGVQISSGDTLARIPQESGG
TKDITGGLPRVADLFEARRPKEPAILAEISGIVSFGKETKGKRRLVITPV
DGSDPYEEMIPKWRQLNVFEGERVERGDVISDGPEAPHDILRLRGVHAVT
RYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKATIVNAGSSDFLEGEQV
EYSRVKIANRELEANGKVGATYSRDLLGITKASLATESFISAASFQETTR
VLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6z9t Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		R47 K118 E211 K332 K334 Y795 Q1326 E1327 T1329 R1330
Binding residue
(residue number reindexed from 1)		R32 K103 E196 K302 K304 Y765 Q1296 E1297 T1299 R1300
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006879 intracellular iron ion homeostasis
GO:0009408 response to heat
GO:0031564 transcription antitermination
GO:0032784 regulation of DNA-templated transcription elongation
GO:0036460 cellular response to cell envelope stress
GO:0042128 nitrate assimilation
GO:0044780 bacterial-type flagellum assembly
GO:0046677 response to antibiotic
GO:0048870 cell motility
GO:0071973 bacterial-type flagellum-dependent cell motility
GO:0090605 submerged biofilm formation
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008023 transcription elongation factor complex
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6z9t, PDBe:6z9t, PDBj:6z9t
PDBsum6z9t
PubMed33243850
UniProtP0A8T7|RPOC_ECOLI DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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