Structure of PDB 6i9r Chain Y Binding Site BS01

Receptor Information
>6i9r Chain Y (length=178) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLEEFFDDPKNWGQEKVKSGAAWTCQQLRNKSNEDLHKLWYVLLKERNML
LTLEQEAKRQRLPMPSPERLDKVVDSMDALDKVVQEREDALRLLQTGQER
ARPGAWRRDIFGRIIWHKFKQWVIPWHLNKRYNRKRFFALPYVDHFLRLE
REKRARIKARKENLERKKAKILLKKFPH
Ligand information
>6i9r Chain A (length=1501) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagcc
aaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgc
aauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaa
uauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaa
uaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcua
ccuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggga
agauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguu
guccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuaa
auccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggac
acuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguag
gccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaa
ucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucac
ccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccucc
gcauaagccugcgucagauaacacaacugacaauuaacagcccaauaucu
acaaucaaccaacaagucauuauuacccucacugucaacccaacacaggc
augcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuua
ccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagagg
caccgccugcccagugacacauguuuaacggccgcgguacccuaaccgug
caaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggc
uccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugc
ccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcu
uuaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguu
ggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacu
ucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaac
aaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaac
aauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagc
cgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugag
uucagaccggaguaauccaggucgguuucuaucuacuuauuccucccugu
acgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccgu
aaaugauaucaucucaacuuaguauacccacacccacccaagaacagggu
u
<<.......<<<<.....................................
<......>.........<.....<<.....>>....>........>>.>>
.............<<....>>......................>>.....
.......<<<.......>>>...<.<........>.>.<<<<<<......
...<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<
<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>.
...>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..
<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<.......
.>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>
...<<<......>>>....<<<.<<<...<..............<....<
<<.........>>>....>.......<<<......>>>............
...............>...>>>>>>........>>>>>>...<<<<<...
...>>>>>.........>>>>>><......<<..<<<....>>><<<<..
<<<<........<<<<<.........>>>>>......<<<...<<<<...
....................>>>>.......>>>.....<<......>>.
>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<
<<<<<..<<<.........>>>...<<<<<<.............>>>>>>
....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>
........<...........<<<<<<.....>>>>>>.....>....>>>
....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<
<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<
..<<<<..<<<<<<<<...............>>>>>>>>.>>>>..<<<<
.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<
.....>>>>..>>>....>>.........<<<....>>>...........
.>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...
>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<.....
.>>>>>>...>>.<<<<.......>>>>.....>>>>>..>...>>>.>>
....<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<.....
............>>>.>>><<<<<...<<<....>>>.>>>>>......<
<<................>>>..............<<<<.......>>>>
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6i9r Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		Q117 R121 R123 R162 R164 R175 K180 K182 V185 I186 H189 L190 K192 R193 N195 R196 K197 R198 R213 R222 N225 L226 R228 K229 K230 K232
Binding residue
(residue number reindexed from 1)		Q55 R59 R61 R100 R102 R113 K118 K120 V123 I124 H127 L128 K130 R131 N133 R134 K135 R136 R151 R160 N163 L164 R166 K167 K168 K170
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0008150 biological_process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6i9r, PDBe:6i9r, PDBj:6i9r
PDBsum6i9r
PubMed33910005
UniProtQ9HD33|RM47_HUMAN Large ribosomal subunit protein uL29m (Gene Name=MRPL47)

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