Structure of PDB 6g90 Chain Y Binding Site BS01

Receptor Information

>6g90 Chain Y (length=84) Species: 4932 (Saccharomyces cerevisiae)

NTLYVSQLNEKINMQRLRVNLFLLFATFGEVLKVSMNFKKQRGQAFITMR
TIDQASLAQISLNGERFFGKPLKVEFSKSETKTL

Ligand information

>6g90 Chain 2 (length=143)

aaguguaguaucuguucuuuucaguguaacaacugaaaugaccuaggcuc
auacacauuuuuuggcaggacgggaagaggagacgucgcgacccucgcag
agucguucuugacuuggucgcuugauguuucuucuucccguuc

...................<<<<<<......>>>>>><<<<<<..>>.>>
>>................<<<<<<<<<<.<<<<<<<<<<<<.<<.....<
<<<<<....>>>>>>>>>>>>..>>>>>>>>.>>>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6g90 Prespliceosome structure provides insights into spliceosome assembly and regulation.
• Resolution: 4.0 Å
• Binding residue (original residue number in PDB): Y31 S33 E37 K38 I39 N40 M41 Q42 R43 Q68 R69 Q71 F73 S104 K105 S106
• Binding residue (residue number reindexed from 1): Y4 S6 E10 K11 I12 N13 M14 Q15 R16 Q41 R42 Q44 F46 S77 K78 S79

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0030620 U2 snRNA binding

Biological Process

• GO:0000398 mRNA splicing, via spliceosome
• GO:0006397 mRNA processing
• GO:0008380 RNA splicing
• GO:1903241 U2-type prespliceosome assembly

Cellular Component

• GO:0005634 nucleus
• GO:0005681 spliceosomal complex
• GO:0005686 U2 snRNP
• GO:0071004 U2-type prespliceosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6g90, PDBe:6g90, PDBj:6g90
• PDBsum: 6g90
• PubMed: 29995849
• UniProt: P40567|MSL1_YEAST U2 small nuclear ribonucleoprotein B'' (Gene Name=MSL1)