Structure of PDB 5t0h Chain Y Binding Site BS01

Receptor Information
>5t0h Chain Y (length=378) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNMAPYYEALCKSL
DWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYL
CRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNT
EKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSY
ELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLF
SLYECRYSVFFQSLAVVEQEMKKDWLFAPHYRYYVREMRIHAYSQLLESY
RSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDS
KNWQYQETIKKGDLLLNRVQKLSRVINM
Ligand information
>5t0h Chain e (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MSEKKQPVDLRAELEKHGYKMETS
Receptor-Ligand Complex Structure
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PDB5t0h Structural basis for dynamic regulation of the human 26S proteasome.
Resolution6.8 Å
Binding residue
(original residue number in PDB)		S269 F272 Q273 E279 V296 R300 F329 E333 F337
Binding residue
(residue number reindexed from 1)		S258 F261 Q262 E268 V285 R289 F318 E322 F326
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005838 proteasome regulatory particle
GO:0022624 proteasome accessory complex
GO:0034774 secretory granule lumen
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5t0h, PDBe:5t0h, PDBj:5t0h
PDBsum5t0h
PubMed27791164
UniProtQ15008|PSMD6_HUMAN 26S proteasome non-ATPase regulatory subunit 6 (Gene Name=PSMD6)

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