Structure of PDB 6zsc Chain XS Binding Site BS01

Receptor Information
>6zsc Chain XS (length=160) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SYLPGYVPKTSLSSPPWPEVVLPDPVEETRHHAEVVKKVNEMIVTGQYGR
LFAVVHFASRQWKVTSEDLILIGNELDLACGERIRLEKVLLVGADNFTLL
GKPLLGKDLVRVEATVIEKTESWPRIIMRFRKRKNFKKKRIVTTPQTVLR
INSIEIAPCL
Ligand information
>6zsc Chain XA (length=1500) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggg
aagauuuauagguagaggcgacaaaccuaccgagccuggugauagcuggu
uguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccaa
auccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggac
acuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguag
gccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaa
ucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucac
ccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccucc
gcauaagccugcgucagauaaccaacugacaauuaacagcccaauaucua
caaucaaccaacaagucauuauuacccucacugucaacccaacacaggca
ugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuac
cccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggc
accgccugcccagugacacauguuuaacggccgcgguacccuaaccgugc
aaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcu
ccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcc
cgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuu
uaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguug
gggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuu
caccagucaaagcgaaccucaauugauccaauaacuugaccaacggaaca
aguuacccuagggauaacagcgcaauccuauucuagaguccauaucaaca
auaggguuuacgaccucgauguuggaucaggacaucccgauggugcagcc
gcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugagu
ucagaccggaguaauccaggucgguuucuaucuacuuauuccucccugua
cgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccgua
aaugauaucaucucaacuuagaauacccacacccacccaagaacaggguu
<<<.......<<<<....................................
.<......>.........<.....<<.....>>....>........>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....
<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>
....>>>.>>>>>...<<.......>>......>.>>>>......>.>>.
.<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......
.>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>
...<<<......>>>....<<<.<<<...<..............<....<
<<.........>>>....>.......<<<......>>>............
...............>...>>>>>>........>>>>>>...<<<<<...
...>>>>>.........>>>>>><......<<..<<<....>>><<<<..
<<<<........<<<<<........>>>>>......<<<...<<<<....
...................>>>>.......>>>.....<<......>>.>
>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<
<<<<..<<<.........>>>...<<<<<<.............>>>>>>.
...<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>.
.......<...........<<<<<<.....>>>>>>.....>....>>>.
...>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<
<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<.
.<<<<<.<<<<<<<<...............>>>>>>>>>>>>>..<<<<.
....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.
....>>>>..>>>....>>.........<<<....>>>............
>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>
>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......
>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>.
...<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<......
...........>>>.>>><<<<<...<<<....>>>.>>>>>......<<
<................>>>..............<<<<.......>>>>.
Receptor-Ligand Complex Structure
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PDB6zsc Structural basis of mitochondrial translation.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		W61 P62 S103 R104 N118 R169 R173 F174 R175 K176 R177 K178 K182 R184
Binding residue
(residue number reindexed from 1)		W17 P18 S59 R60 N74 R125 R129 F130 R131 K132 R133 K134 K138 R140
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6zsc, PDBe:6zsc, PDBj:6zsc
PDBsum6zsc
PubMed32812867
UniProtQ7Z2W9|RM21_HUMAN Large ribosomal subunit protein bL21m (Gene Name=MRPL21)

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