Structure of PDB 6otr Chain XR Binding Site BS01

Receptor Information
>6otr Chain XR (length=70) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KAKVKATLGEFDLRDYRNVEVLKRFLSETGKILPRRRTGLSAKEQRILAK
TIKRARILGLLPFTEKLVRK
Ligand information
>6otr Chain XA (length=1507) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaag
acaugcaagucgugcgggccgcggccguggucagcggcggacgggugagu
aacgcgugggugaccuacccggaagagggggacaacccggggaaacucgg
gcuaaucccccauguggacccgccccuugggguguguccaaagggcuuug
cccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaaugg
cccaccaaggcgacgacggguagccggucugagaggauggccggccacag
gggcacugagacacgggccccacuccuacgggaggcagcaguuaggaauc
uuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaag
cccuucgggguguaaacuccugaacccgggacgaaacccccgacgagggg
acugacgguaccgggguaauagcgccggccaacuccgugccagcagccgc
gguaauacggagggcgcgagcguuacccggauucacugggcguaaagggc
guguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugg
gggagcgugggauacgcucaggcuagacggugggagagggugguggaauu
cccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcga
aggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggag
caaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcua
ggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccu
ggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgc
acaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuac
caggccuugacaugcuagggaacccgggugaaagccuggggugccccgcg
aggggagcccuagcacaggugcugcauggccgucgucagcucgugccgug
agguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugcc
agcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaa
ggaggggacgacgucuggucagcauggcccuuacggccugggcgacacac
gugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaa
ucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccau
gaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacg
uucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuac
ccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugac
uggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca
ccuccuu
......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<
<<.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<....
...<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>
>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>
>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......
>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<
<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>......
..<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<
<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>
..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>
.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<
<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>
....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<
<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<..
..>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<
<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..
<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.
<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.
<<.<<<<<<..<<<<<<<<<<......<<........>>..........<
<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<....
...>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<...
.>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<.
..<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>.....
...>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>
>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>...
.>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>.
...>.....>>>>>>....<<<<<<<..........>>>>>>>......>
>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<
<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>
>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......
.......
Receptor-Ligand Complex Structure
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PDB6otr Monomeric YoeB toxin retains RNase activity but adopts an obligate dimeric form for thermal stability.
Resolution3.12 Å
Binding residue
(original residue number in PDB)		K49 I50 R53 K61 Q63 R64 K68 K71 R72 R74 I75 F81
Binding residue
(residue number reindexed from 1)		K31 I32 R35 K43 Q45 R46 K50 K53 R54 R56 I57 F63
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0070181 small ribosomal subunit rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6otr, PDBe:6otr, PDBj:6otr
PDBsum6otr
PubMed31501867
UniProtQ5SLQ0|RS18_THET8 Small ribosomal subunit protein bS18 (Gene Name=rpsR)

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