Structure of PDB 6otr Chain XO Binding Site BS01

Receptor Information
>6otr Chain XO (length=87) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PITKEEKQKVIQEFARFPGDTGSTEVQVALLTLRINRLSEHLKVHKKDHH
SHRGLLMMVGQRRRLLRYLQREDPERYRALIEKLGIR
Ligand information
>6otr Chain XA (length=1507) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaag
acaugcaagucgugcgggccgcggccguggucagcggcggacgggugagu
aacgcgugggugaccuacccggaagagggggacaacccggggaaacucgg
gcuaaucccccauguggacccgccccuugggguguguccaaagggcuuug
cccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaaugg
cccaccaaggcgacgacggguagccggucugagaggauggccggccacag
gggcacugagacacgggccccacuccuacgggaggcagcaguuaggaauc
uuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaag
cccuucgggguguaaacuccugaacccgggacgaaacccccgacgagggg
acugacgguaccgggguaauagcgccggccaacuccgugccagcagccgc
gguaauacggagggcgcgagcguuacccggauucacugggcguaaagggc
guguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugg
gggagcgugggauacgcucaggcuagacggugggagagggugguggaauu
cccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcga
aggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggag
caaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcua
ggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccu
ggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgc
acaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuac
caggccuugacaugcuagggaacccgggugaaagccuggggugccccgcg
aggggagcccuagcacaggugcugcauggccgucgucagcucgugccgug
agguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugcc
agcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaa
ggaggggacgacgucuggucagcauggcccuuacggccugggcgacacac
gugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaa
ucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccau
gaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacg
uucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuac
ccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugac
uggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca
ccuccuu
......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<
<<.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<....
...<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>
>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>
>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......
>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<
<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>......
..<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<
<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>
..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>
.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<
<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>
....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<
<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<..
..>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<
<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..
<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.
<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.
<<.<<<<<<..<<<<<<<<<<......<<........>>..........<
<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<....
...>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<...
.>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<.
..<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>.....
...>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>
>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>...
.>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>.
...>.....>>>>>>....<<<<<<<..........>>>>>>>......>
>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<
<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>
>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......
.......
Receptor-Ligand Complex Structure
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PDB6otr Monomeric YoeB toxin retains RNase activity but adopts an obligate dimeric form for thermal stability.
Resolution3.12 Å
Binding residue
(original residue number in PDB)		P2 K5 K8 Q9 T22 G23 S24 Q28 L31 R35 L39 H42 H46 K48 D49 H50 H51 S52 R54 M58 R64 R65 Y69 R72
Binding residue
(residue number reindexed from 1)		P1 K4 K7 Q8 T21 G22 S23 Q27 L30 R34 L38 H41 H45 K47 D48 H49 H50 S51 R53 M57 R63 R64 Y68 R71
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6otr, PDBe:6otr, PDBj:6otr
PDBsum6otr
PubMed31501867
UniProtQ5SJ76|RS15_THET8 Small ribosomal subunit protein uS15 (Gene Name=rpsO)

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