Structure of PDB 4p6f Chain XM Binding Site BS01

Receptor Information
>4p6f Chain XM (length=121) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEA
EVVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQ
RTRTNARTRKGPRKTVAGKKK
Ligand information
>4p6f Chain XA (length=1500) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcggggacuccguggucagcggcggacgggug
aguaacgcgugggugaccuacccggaagagggggacaacccggggaaacu
cgggcuaaucccccauguggacccgccccuugggguguguccaaagggcu
uugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaa
uggcccaccaaggcgacgacggguagccggucugagaggauggccggcca
caggggcacugagacacgggccccacuccuacgggaggcagcaguuagga
aucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaag
aagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgag
gggacugacgguaccgggguaauagcgccggccaacuccgugccagcagc
cgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaag
ggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccg
ugggggagcgugggauacgcucaggcuagacggugggagaggguggugga
auucccggaguagcggugaaaugcgcagauaccgggaggaacgccgaugg
cgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggg
gagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcg
cuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccg
ccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcc
cgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccu
uaccaggccuugacaugcuagggaacccgggugaaagccuggggugcccc
gcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugcc
gugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguu
gccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggag
gaaggaggggacgacgucuggucagcauggcccuuacggccugggcgaca
cacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagc
uaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccc
caugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaau
acguucccgggccuuguacacaccgcccgucacgccaugggagcgggcuc
uacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgu
gacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga
....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<
.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.
......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>
>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<.
..>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<....
...>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>
>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>...
.....<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<....
..<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>
>>>..........>>>>>......<<<<<(((...<<<<<.....<<.))
)>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((....
.<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>
>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<...
.<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<
<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<.
..<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<
<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>
>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<
<<.<<.<<<<<<..<<<<<<<<<<......<<........>>........
..<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<
....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<
....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..
.<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>..
......>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.
>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>
....>>>.....>>>>>>>......<....<<<<<<<........>>>>>
>>....>.....>>>>>>....<<<<<<<..........>>>>>>>....
..>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<
<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>
..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...
Receptor-Ligand Complex Structure
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PDB4p6f Macrolide-Peptide Conjugates as Probes of the Path of Travel of the Nascent Peptides through the Ribosome.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		R14 Y21 Y23 G24 I25 G26 K27 A28 R29 R44 V74 N77 Y87 R88 R91 H92 L96 P97 V98 R99 Q101 R102 T103 R104 T105 N106 A107 R108 T109 R110 K111 K115 T116 K121
Binding residue
(residue number reindexed from 1)		R13 Y20 Y22 G23 I24 G25 K26 A27 R28 R43 V73 N76 Y86 R87 R90 H91 L95 P96 V97 R98 Q100 R101 T102 R103 T104 N105 A106 R107 T108 R109 K110 K114 T115 K120
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4p6f, PDBe:4p6f, PDBj:4p6f
PDBsum4p6f
PubMed25198768
UniProtP80377|RS13_THET8 Small ribosomal subunit protein uS13 (Gene Name=rpsM)

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