Structure of PDB 6nsh Chain XD Binding Site BS01

Receptor Information
>6nsh Chain XD (length=208) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRYIGPVCRLCRREGVKLYLKGERCYSPKCAMERRPYPPGQHGQKRARRP
SDYAVRLREKQKLRRIYGISERQFRNLFEEASKKKGVTGSVFLGLLESRL
DNVVYRLGFAVSRRQARQLVRHGHITVNGRRVDLPSYRVRPGDEIAVAEK
SRNLELIRQNLEAMKGRKVGPWLSLDVEGMKGKFLRLPDREDLALPVNEQ
LVIEFYSR
Ligand information
>6nsh Chain XA (length=1511) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac
augcaagucgugcgggccgcggggacuccguggucagcggcggacgggug
aguaacgcgugggugaccuacccggaagagggggacaacccggggaaacu
cgggcuaaucccccauguggacccgccccuugggguguguccaaagggcu
uugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaa
uggcccaccaaggcgacgacggguagccggucugagaggauggccggcca
caggggcacugagacacgggccccacuccuacgggaggcagcaguuagga
aucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaag
aagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgag
gggacugacgguaccgggguaauagcgccggccaacuccgugccagcagc
cgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaag
ggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccg
ugggggagcgugggauacgcucaggcuagacggugggagaggguggugga
auucccggaguagcggugaaaugcgcagauaccgggaggaacgccgaugg
cgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggg
gagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcg
cuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccg
ccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcc
cgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccu
uaccaggccuugacaugcuagggaacccgggugaaagccuggggugcccc
gcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugcc
gugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguu
gccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggag
gaaggaggggacgacgucuggucagcauggcccuuacggccugggcgaca
cacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagc
uaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccc
caugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaau
acguucccgggccuuguacacaccgcccgucacgccaugggagcgggcuc
uacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgu
gacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga
ucaccuccuuu
....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<
.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.
......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>
>>>>.....>>>>>....<<<<.<<.<<....>>.>>.>>>>...<<<<.
..>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<....
...>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>
>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>...
.....<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<....
..<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>
>>>..........>>>>>......<<<<<(((...<<<<<.....<<.))
)>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((....
.<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>
>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<...
.<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<
<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<.
..<<...<<<<.........>>>>...>>>>>>>>..........<<<<<
<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>
>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<
<<.<<.<<<<<<..<<<<<<<<<<......<<........>>........
..<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<.<
.....>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<
....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..
.<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>..
......>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.
>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>
....>>>.....>>>>>>>......<....<<<<<<<........>>>>>
>>....>.....>>>>>>....<<<<<<<..........>>>>>>>....
..>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<
<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>
..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...
...........
Receptor-Ligand Complex Structure
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PDB6nsh Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon-anticodon pairing.
Resolution3.397 Å
Binding residue
(original residue number in PDB)
G2 R3 I5 P7 V8 C9 R10 R13 R14 K22 E24 R25 K30 R35 R36 Y38 P40 G41 Q42 H43 Y54 R59 K61 Q62 R66 E72 R73 Q74 K84 K86 V112 S113 R115 Q116 R118 Q119 R122 H123 H125 V133 D134 L135 S137 R141 K151 L157 E205 S208 R209
Binding residue
(residue number reindexed from 1)
G1 R2 I4 P6 V7 C8 R9 R12 R13 K21 E23 R24 K29 R34 R35 Y37 P39 G40 Q41 H42 Y53 R58 K60 Q61 R65 E71 R72 Q73 K83 K85 V111 S112 R114 Q115 R117 Q118 R121 H122 H124 V132 D133 L134 S136 R140 K150 L156 E204 S207 R208
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6nsh, PDBe:6nsh, PDBj:6nsh
PDBsum6nsh
PubMed33016876
UniProtP80373|RS4_THET8 Small ribosomal subunit protein uS4 (Gene Name=rpsD)

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