Structure of PDB 7nwg Chain X2 Binding Site BS01

Receptor Information

>7nwg Chain X2 (length=129) Species: 9986 (Oryctolagus cuniculus)

VRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFE
IIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGF
IVLTTSAGIMDHEEARRKHTGGKILGFFF

Ligand information

>7nwg Chain A2 (length=1740)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucagaucaaaaccaacccggucaggcggcuuuggugac
ucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucga
acgucugcccuaucaacuuucgaugguagucgccgugccuaccaugguga
ccacgggugacggggaaucaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacuccc
gacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggc
ccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauugg
agggcaagucuggugccagcagccgcgguaauuccagcuccaauagcgua
uauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggg
cggccguccguccccugccucucggcgccccggggcccgaagcguuuacu
uugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuagg
aauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugagg
ccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggu
gaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaag
aauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucaga
uaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcg
uuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuugggu
uccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaag
ggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaa
ccucacccggcccggacacggacaggauugacagauugauagcucuuucu
cgauuccgugggugguggugcauggccguucuuaguugguggagcgauuu
gucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuac
gcgaccccggucggcguaacuucuuagagggacaaguggcguucagccac
ccgagauugagcaauaacaggucugugaugcccuuagauguccggggcug
cacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcag
gcgcggguaacccguugaaccccauucgugauggggaucggggauugcaa
uuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugc
guugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgau
uggaugguuuagugaggcccucggaucggccccgccggggugcccuggcg
gagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucg
uaacaagguuuccguaggugaaccugcggaaggaucauua

...<<<<<...(((.>>>>><<<.<<<<<<...<.<<..<......<<..
<<<..<<....<.......................>.>>......<<...
.....<<<.<..........<<<...........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<......>>>>>..
.>>>><<..<<<<<.......(((.....<........>......<....
.>..>>>>>......>>...<<<<..<.....>.>>>>....>>>.....
..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>..
....>>>....<<.<<<<....>>>>....>>..>>.<<.<<.<......
...>>>.>>...<<....>>.....>>>.>>.........<<<....<<<
.....>>>..>>>..>...>>.>.....<<<.<<<<..<<<....>>>..
.>>>>..>>>......<<..<...........>..>>.........<<<<
<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>
>.>>>...........<[[.....<.<<...<<<.<<....<<<.<<<<.
<<..>>.>>>>.>>>....<........<<..>.>.....>....<<<<<
<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>
..>>>..........<<.<<<<<<<.........)))...>>>>>>>.>>
......>>....<<<<<<......<<<<...<..<<<<<<<<...<<<..
....>>>......>>>>>>>>..>........<<....>>...>>>>...
..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<....
.>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<
<<<......>>>>>>>>>>.>..>>>...<<..]]>>...>>.....>>>
.>...<<<......<<<......>>>....>>>...)))..<<<<<.<<<
<<<<..<<..<<<<...<<<.<<<<<<......<<........>>.....
.....<<.<<......<<..<<.......<<.<<<........>>>.>>.
....>>..>>...<..<<<..<<.<<<<<.....<<<.<<<<......>>
...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<
<.<.<....>>...>>>>>>>..>>>>..>.....<<<<<.....>>>>>
........>>>.....>>.>>>.....>>>>>.>.......>>.>>...>
>.>>>>.>>>.....<<.<<<................<<<.<<<<....>
>>>.>>>..............>>>.>>.............<<<<......
....>>>>.............>>>>.....<<<<<<<<.......>>>>>
>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<..<...
.<<<<<<<<.<<<..<<.<<<<...<<<<<.<<<<<<<<<..>>>>>>>>
>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>..>>>>...>.>>
...>.....<<<<<<<<<....>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7nwg Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): V2 M4 N16 R20 R28 K32 K71 S76 D80 Q82 K88 T105 T106 S107 H120 G122
• Binding residue (residue number reindexed from 1): V1 M3 N15 R19 R27 K31 K70 S75 D79 Q81 K87 T104 T105 S106 H119 G121

Gene Ontology

--> -->

UnboundLocalError

Python 3.6.8: /usr/bin/python3 Fri Nov 15 11:42:14 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1435     title=pdb2title(pdbid)

   1436     if bs.startswith("BS"):

=> 1437         pubmed,uniprot=display_interaction(pdbid,asym_id,bs,title)

   1438     else:

   1439         if lig3:

pubmed = '', uniprot = '', display_interaction = <function display_interaction>, pdbid = '7nwg', asym_id = 'X2', bs = 'BS01', title = 'Blasticidin S inhibits mammalian translation and...s production of protein encoded by nonsense mRNA.'

 /var/www/html/BioLiP/pdb.cgi in display_interaction(pdbid='7nwg', asym_id='X2', bs='BS01', title='Blasticidin S inhibits mammalian translation and...s production of protein encoded by nonsense mRNA.')

   1295         display_ec(ec,csaOrig,csaRenu)

   1296     if go:

=> 1297         display_go(go,uniprot,pdbid,asym_id)

   1298     return pubmed,uniprot

   1299 

global display_go = <function display_go>, go = '0003735,0005840,0006412', uniprot = '', pdbid = '7nwg', asym_id = 'X2'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0003735,0005840,0006412', uniprot='', pdbid='7nwg', asym_id='X2')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>