Structure of PDB 8q7n Chain X Binding Site BS01

Receptor Information

>8q7n Chain X (length=81) Species: 9606 (Homo sapiens)

ADYWKSQPKKFCDYCKCWIADNRPSVEFHERGKNHKENVAKRISEIKQKS
LDKAKEEEKASKEFAAMEAAALKAYQEDLKR

Ligand information

>8q7n Chain 6 (length=78)

gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaaga
uuagcauggccccugcgcaaggaugaca

<<<<<.<<....>>>>>>>...............................
............................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8q7n New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): D3 Y4 W5 K6 S7 Q8 N23 P25
• Binding residue (residue number reindexed from 1): D2 Y3 W4 K5 S6 Q7 N22 P24

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding
• GO:0070064 proline-rich region binding

Biological Process

• GO:0000398 mRNA splicing, via spliceosome
• GO:0006397 mRNA processing
• GO:0008380 RNA splicing
• GO:0045292 mRNA cis splicing, via spliceosome

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005681 spliceosomal complex
• GO:0016607 nuclear speck
• GO:0071005 U2-type precatalytic spliceosome
• GO:0071011 precatalytic spliceosome

External links

• PDB: RCSB:8q7n, PDBe:8q7n, PDBj:8q7n
• PDBsum: 8q7n
• PubMed: 38383864
• UniProt: O75554|WBP4_HUMAN WW domain-binding protein 4 (Gene Name=WBP4)