Structure of PDB 8etu Chain X Binding Site BS01

Receptor Information
>8etu Chain X (length=442) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRTAAHTHIKGLGLDESGVAKRVEGGFVGQIEAREACGVIVDLIKAKKMS
GRAILLAGGPSTGKTALALAISQELGPKVPFCPLVGSELYSVEVKKTETL
MENFRRAIGLRIKETKEVYEGEVTELTPEDAENPLGGYGKTISHVIVGLK
SAKGTKTLRLDPTIYESIQREKVSIGDVIYIEANTGAVKRVGRSDAYATE
FDLETEEYVPLPKGEVHKKKEIVQDVTLHDLDVANARPQGGQDVISMMGQ
LLKPKKTEITEKLRQEVNKVVAKYIDQGVAELIPGVLFIDEVNMLDIEIF
TYLNKALESNIAPVVVLASNRGMTTVRGTEDVISPHGVPPDLIDRLLIVR
TLPYDKDEIRTIIERRATVERLQVESSALDLLATMGTETSLRYALQLLAP
CGILAQTSNRKEIVVNDVNEAKLLFLDAKRSTKILETSANYL
Ligand information
>8etu Chain Z (length=28) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
FVKPRRPYNSEGMTRILRRYEEDLFCTF
Receptor-Ligand Complex Structure
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PDB8etu Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		L156 Y159 G160 I163 E187
Binding residue
(residue number reindexed from 1)		L135 Y138 G139 I142 E166
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
GO:0043139 5'-3' DNA helicase activity
Biological Process
GO:0000492 box C/D snoRNP assembly
GO:0006281 DNA repair
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0032508 DNA duplex unwinding
GO:0050821 protein stabilization
Cellular Component
GO:0000785 chromatin
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0031011 Ino80 complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0097255 R2TP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8etu, PDBe:8etu, PDBj:8etu
PDBsum8etu
PubMed37384669
UniProtQ03940|RUVB1_YEAST RuvB-like protein 1 (Gene Name=RVB1)

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