Structure of PDB 8b9a Chain X Binding Site BS01

Receptor Information
>8b9a Chain X (length=665) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADFSLTVLRARIALLATAIGGPDYTSQIDPPPYKLGDDCLACLKDLKRWF
KLVDDQQKRWDVAMAVAEYRILTDDLLPILIDWENKCSLAAKLANKAYYD
KIALNCLQLLVLMTWPLIVTEQSSSNQITLYGELKKHQLVYKKTILSMES
GKVLRAAIRLALDVIKIDRLSRTPRDNMVLKLVLNFFRNVIAIEPGEFTI
NTKKSMDTLPPNVSMDDISLNTVISSFHKNKVFGFLLTLTSSLSKEFDQD
FINIPLLEIMFYFTKDVNQELLFPRTSAGFELSKLLQKEHQMRKNVIKHT
SARHSRFGGLLSIQTPDKTRLTVSGSQALVDEKIALQKLDDSKKWNKRII
KAAEGLPNSLLNSQTGKAIFFTESNGKHFKEFINNFIDSGFNILLHSVTN
YFTTEQDRMVTLEQVEYLLFFAWFVKYQLLRSKIDNSADIKQVSEALKEV
TFILVSSLLRSAYDLKNWTVTHAGMIAFNELLNLVSRTKAATDIEFIVSR
LFSDERIQLLSNLPKIGSKYSLQFMKSCIELTHSVLKVLEQYSNFQKVQA
NYMTEPVIETYINFLERFRELEDDSIKKVFSFFHRVFVQAKEQALLFRFD
LIILLREMLSPDGLDRMSRSRKYVSQFSDYFLARLKKRLKKSPAWFVGLL
FPPLHNSEVGFYQRY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8b9a How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		K400 I403
Binding residue
(residue number reindexed from 1)		K347 I350
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0000076 DNA replication checkpoint signaling
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0007064 mitotic sister chromatid cohesion
GO:0008156 negative regulation of DNA replication
GO:0031297 replication fork processing
GO:0043111 replication fork arrest
GO:0043570 maintenance of DNA repeat elements
GO:0051321 meiotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0031298 replication fork protection complex
GO:0043596 nuclear replication fork

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8b9a, PDBe:8b9a, PDBj:8b9a
PDBsum8b9a
PubMed37506699
UniProtP53840|TOF1_YEAST Topoisomerase 1-associated factor 1 (Gene Name=TOF1)

[Back to BioLiP]