Structure of PDB 7oi7 Chain X Binding Site BS01

Receptor Information

>7oi7 Chain X (length=243) Species: 9606 (Homo sapiens)

PLHKYPVWLWKRLQLREGICSRLPGHYLRSLEEERTPTPVHYRPHGAKFK
INPKNGQRERVEDVPIPIYFPPESQRGLWGGEGWILGQIYANNDKLSKRL
KKVWKPQLFEREFYSEILDKKFTVTVTMRTLDLIDEAYGLDFYILKTPKE
DLCSKFGMDLKRGMLLRLARQDPQLHPEDPERRAAIYDKYKEFAIPEEEA
EWVGLTLEEAIEKQRLLEEKDPVPLFKIYVAELIQQLQQQALS

Ligand information

>7oi7 Chain A (length=1054)

gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaa
accauuuacauaaaguauaggcgauagaaauugggcgcaauagauauagu
accgcaagggaaagaugaaaaauaccaagcauaauauagcaaggacuaac
cccuauaccuucugaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagauuuauagg
uagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauag
aaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaa
uuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaac
cuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagc
caccaauuaagaaagcguucaagcucaacaccucccaaacauauaacuga
acuccucacacccaauuggaccaaucuaucacccuauagaagaacuaaug
uuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucaga
ucacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuau
uacccucacugucaacccaacaggcaugcucauaaggaaagguuaaaaaa
aguaaaaggaaacaucaccucuagcaucaccaguauuagaggccagcugu
cucuuacuuuuaaccagugaaauugaccugcccgugaggcgggcauaaca
cagcaagacgagacccuauggagcuuuaauuuauuaaugcaaacaccugc
auuaaaaauuucaguacaugcuaagacuucaccagucaaagcgaaccuca
auugauccaauaacuugaccaacggaacaaguuacccuaggguaucuacu
uuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaa
gcgccuucuaaaugauaucaucucaacuuaauacccacacccaagaacag
gguu

<<<.......<<<<..................................<.
.....>.....<.....<<.....>>....>..>>.>>............
.<<....>>..................>>>...........<<<......
.>>>...<.<....>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<....>>>.>>>>
>...<<.......>>......>.>>>>......>.>>..<<<<<<....<
<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>
>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>
>>....<<<.<<<...<..............<....<<<.........>>
>....>.......<<<......>>>......................>..
.>>>>>>........>>>>>>...<<<<<......>>>>>.........>
>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.
...>>>>>......<<<...<<<<.......................>>>
>.......>>>.....<<....>>.>>>>.....>>>>..<<<<...<<<
<<<<<.<<.........<<<<<<.............>>>>>>........
>>.>>>>>>>>>>>>.>>.....>.....<<<<<.....>>>>>......
.<<..<<<.....<<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>
>>>>>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>..
.......<<<....>>>............>>>>..>>>>>>>..>>>.>>
..<<<.<<<.................>>>.>>><<<<<...<<<....>>
>.>>>>>.<<<.<............>.>>>........<<<<.......>
>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7oi7 A distinct assembly pathway of the human 39S late pre-mitoribosome.
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): L3 K5 Y6 E18 K55 N56 Y70 L87 Y91 K96 L97 S98 K99 R100 L101 K102 K103 V104 W105 Q108 F110
• Binding residue (residue number reindexed from 1): L2 K4 Y5 E17 K54 N55 Y69 L86 Y90 K95 L96 S97 K98 R99 L100 K101 K102 V103 W104 Q107 F109

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005761 mitochondrial ribosome
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7oi7, PDBe:7oi7, PDBj:7oi7
• PDBsum: 7oi7
• PubMed: 34315873
• UniProt: Q13084|RM28_HUMAN Large ribosomal subunit protein bL28m (Gene Name=MRPL28)