Structure of PDB 7nhk Chain X Binding Site BS01

Receptor Information
>7nhk Chain X (length=101) Species: 1351 (Enterococcus faecalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MFVKKGDKVKVITGKDKNKEGVVLAAFPKQDKVIVEGVNVVKKHQKPNQA
APQGGILEVEAPIHVSNVMVIDPSNGEATKVAFKEVDGKKVRVSKKTGEV
L
Ligand information
>7nhk Chain A (length=2905) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgauga
aggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuauga
uccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacu
uuucagugaauacauagcugauuagagguagacgcagagaacugaaacau
cuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcg
agcgaaacgggaagagcccaaaccaacaagcuuguugggguuguaggacu
ccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcua
aagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauc
cugaguacggcggaacacgagaaauuccgucggaauccgcggggaccauc
ccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugag
ggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccg
ugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuug
uagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagac
ggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucgu
agacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaa
acgcacuggaggaccgaacccacguacguugaaaagugcggggaugaggu
guggguagcggagaaauuccaaacgaacuuggagauagcugguucucucc
gaaauagcuuuagggcuagccucggaauugagaaugauggagguagagca
cuguuuggacuaggggcccaucucggguuaccgaauucagauaaacuccg
aaugccauucauuuauauccgggagucagacugcgagugauaagauccgu
agucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauaug
uuaaguggaaaaggaugugggguugcacagacaacuaggauguuggcuua
gaagcagccaccauuuaaagagugcguaauagcucacuagucgagugacc
cugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacua
caccauuagguguagugguaggagagcguucuaagggcguugaaggucga
ucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagc
gaaagacaggugagaauccuguccaccguaugacuaagguuuccugggga
aggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcg
uaggcgauggacaacagguugauauuccuguaccaguuguuuuuguuuga
gcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcau
guccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggac
aaguugugacggggagcgaaauaauaguagcgaaguuccugacgucacac
ugccaagaaaagcuucuagugagaaaacaacugcccguaccguaaaccga
cacagguagucgaggagaguauccuaaggugagcgagcgaacucucguua
aggaacucggcaaaaugaccccguaacuucgggagaaggggugcugacuu
cggucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacagg
ucucugcaaaaucguaagaugaaguauaggggcugacgccugcccggugc
uggaagguuaagaggauggguuagcuucggcgaagcucagaauugaagcc
ccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccu
ugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugu
cucaacgagagacucggugaaauuuuaguaccugugaagaugcagguuac
ccgcgacaggacggaaagaccccauggagcuuuacuguaguuugauauug
aguguuuguaccacauguacaggauagguaggagccgaugagaccggaac
gcuaguuucggaggaggcgcuggugggauacuacccuuguguuaugaacc
cucuaacccgcaccacuaaucguggugggagacagugucagaugggcagu
uugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguuc
ccucagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcu
ugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugau
ccggugguuccgcauggaagggccaucgcucaacggauaaaagcuacccu
ggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuu
ggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaag
gguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgu
cgugagacaguucggucccuauccgucgcgggcguuggaaauuugagagg
agcuguccuuaguacgagaggaccgggauggacuuaccgcugguguacca
guuguucugccaagggcauugcuggguagcuauguagggaagggauaaac
gcugaaagcaucuaagugugaagcccaccucaagaugagauuucccauuu
cuuuaagaaaguaagaccccugagagaugaucagguagauagguuggaag
uggaaggcuagugauaguuggagcggaccaauacuaaucggucgaggacu
uaacc
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....<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>..>>
>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>
>>>>..)))......]].>>>>>>>.]]...............<<....>
>....]].........<<<<....>>>>..................>>>>
>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<....
....>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>
...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>
>..<<.<...<<<.<<.....<<<<<<<<<..<<<....<<<<<<.....
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....<<<<<....>>>>><<<<<<<<.....<<<<<<<<<.....<<<..
.<<<<<<<<...<<.<<<<.....>>>>..>>...>>>>>>>>..>>.>.
....>>>>.>>>>>...>>>>>>.>>..<<<<<<<.<<......>>.>>>
>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<
<...........<<..<<<<<<<<<........<<<<<.<<...<<<...
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....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.
<<...............<<<<<...............>>>>><<<<<<..
..>>>>>>............<<<<<<<<<..<<<.........>>>..<<
<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<
<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>
>>>>>..>>>>><<<<<<.......>>>>>>........<..........
.<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....
>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<
<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<
<<.<<<<<<<.<<<<...........<<<<<..<<<.......<<<<<<<
....>>>>>>>....>>>............>>>>>..>>>>.>>>>>>>.
>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>
..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<
<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>
...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))].....
.<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>
>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....
>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..
>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<
<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<
..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<
<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<
<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<
<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<
<.....<<<<....>>>>....>>...>>>>>.>>>...>>>>....>>>
>>...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7nhk Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens.
Resolution2.9 Å
Binding residue
(original residue number in PDB)
F2 K4 K5 G14 K15 V41 K42 K43 H44 Q49 G55 I56 S66 N67 K80 A82 F83 K90 K95
Binding residue
(residue number reindexed from 1)
F2 K4 K5 G14 K15 V41 K42 K43 H44 Q49 G55 I56 S66 N67 K80 A82 F83 K90 K95
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7nhk, PDBe:7nhk, PDBj:7nhk
PDBsum7nhk
PubMed34117249
UniProtA0A1B4XKV5

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