Structure of PDB 7a5p Chain X Binding Site BS01

Receptor Information
>7a5p Chain X (length=93) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IRPNHTIYINNMNDKIKKEELKRSLYALFSQFGHVVDIVALKTMKMRGQA
FVIFKELGSSTNALRQLQGFPFYGKPMRIQYAKTDSDIISKMR
Ligand information
>7a5p Chain 2 (length=155) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcuucucggccuuucuuaucaguuuaauaucugauacguccucuauccg
aggacaauauauuaaauggauuuuuggagcagggagauggaauaggagcu
ugcuccguccacuccacgcaucgaccugguauugcaguaccuccaggaac
ggugc
........................<<<<<<<........<<<<<.....>
>>>>....>>>>>>>..................<<<.<<<<...<<<<..
..>>>>.>>>>>>>...<<<<<<.<<<<<.............>>>>>..>
>>>>>
Receptor-Ligand Complex Structure
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PDB7a5p Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome.
Resolution5.0 Å
Binding residue
(original residue number in PDB)		Y13 K22 K23 V44 A45 K50 M51 R52 F56 S95 K96 R98
Binding residue
(residue number reindexed from 1)		Y8 K17 K18 V39 A40 K45 M46 R47 F51 S90 K91 R93
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030619 U1 snRNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005685 U1 snRNP
GO:0005686 U2 snRNP
GO:0016607 nuclear speck
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0071005 U2-type precatalytic spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7a5p, PDBe:7a5p, PDBj:7a5p
PDBsum7a5p
PubMed33007253
UniProtP08579|RU2B_HUMAN U2 small nuclear ribonucleoprotein B'' (Gene Name=SNRPB2)

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