Structure of PDB 6y7c Chain X Binding Site BS01

Receptor Information
>6y7c Chain X (length=144) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKGKPRGLNSARKLRVHRRNNRWAENNYKKRLLGTAFKSSPFGGSSHAKG
IVLEKLGIESKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDE
VLLAGFGRKGKAKGDIPGVRFKVVKVSGVSLLALWKEKKEKPRS
Ligand information
>6y7c Chain 2 (length=1735) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguu
ggccggucggauuuccaacggggccuuuccuucuggcuaaccaggacuuu
uacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauau
uagcauggaauaauagaauaggacguuugguucuauuuuguugguuucua
ggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauu
gucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagca
uuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaag
augaucagauaccgucguagucuuaaccauaaacuaugccgacuagggau
cgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaag
ucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaau
ugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaa
cacggggaaacucaccagguccagacacaauaaggauugacagauugaga
gcucuuucuugauuuugugggugguggugcauggccguucuuaguugguu
uugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagug
gugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaa
gccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguuc
ugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggcc
gagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcau
uguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucag
cuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuagua
ccgauugaauggcuuagugaggccucaggaucugcuuagagaucucagag
cggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaaca
agguuuccguaggugaaccugcggaaggaucauua
...<<<<......[[.>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<............>...>>.>>......<<..
......<<<..<<..<<....<<<..................<.....<<
.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>
>>><...<<<<<<......((((((................<<......>
>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>
>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<.<....>.>>....>>>.>>.<<.<<<.......
...>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<
.....>>>..>>>..>....>.>.....<<<.<<<<<<<<......>>>>
>>>>..>>>......<<.................>>.........<<<<<
((......<<<<.....<...)).>.......>>>>.>>>>>..>>>>>>
>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<
<<............>>>>>>.>>>>>.......<<<....>>>......<
<<<<.<<.......<<...<.......>..<<<.....>>>....>>...
...>>.>>..>>>..............<<<<.<<.......))))))..>
>.>>>>.........>>....<<<.<<.<<...<<<<..<<..<<<<<<.
....<<........>>........>>>>>>..>>......<<<....>>>
..>>>>..>>.>>..>>>...>>>...>>.>....<<<<<<..<.<...<
<<<.........>>>>...>>>>>>>>..........<<<..<.<<<..<
<<<<<<..<<..........>>.>>>>>>>..>>>...<<..]]>>...>
......>>>.>>>.<<<......<<<<....>>>>....>>>..]]....
...<<.<<<<<<<..<<..<<<....<<<.<<<<<<..............
..............<<<<<......<<.<<...........<<<......
..>>.>........>>.>>..........<<<..<<.<......<<.<<.
....................>>.>>.....<<<<........<<..<<<<
<.<<<<<<....>>>>>>...>>>>>..>>...........<<<<.....
>>>>..........>>>>.....>..>>...>>>..............>>
>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<......
..........>>....>>.......>>>>>>>...........<<<<<<.
.........>>>>>>............>>>......<<<<<<<.......
>>>>>>>.......>>...>>>>>>>>>.....<<<....<....<<<<.
<<..<<<<<<<<<<.<<<..<.<<..<...<<<<<<............>>
>>>>...>..>>.>..>>>.>>>>>>>>>>.>>.>>>>.....>......
.>>>.<<<<<<<<....>>>>>>>>..........
Receptor-Ligand Complex Structure
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PDB6y7c Good Vibrations: Structural Remodeling of Maturing Yeast Pre-40S Ribosomal Particles Followed by Cryo-Electron Microscopy.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		K3 K5 R7 N10 R13 K14 R19 R20 N22 R23 W24 A25 E26 K30 R32 S47 H48 K50 I59 E60 P64 N65 R69 K78 D90 A105 G106 G108 R109 K110 K112 K123 K126 S131 L133
Binding residue
(residue number reindexed from 1)		K2 K4 R6 N9 R12 K13 R18 R19 N21 R22 W23 A24 E25 K29 R31 S46 H47 K49 I58 E59 P63 N64 R68 K77 D89 A104 G105 G107 R108 K109 K111 K122 K125 S130 L132
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
GO:0006450 regulation of translational fidelity
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6y7c, PDBe:6y7c, PDBj:6y7c
PDBsum6y7c
PubMed32138239
UniProtP0CX29|RS23A_YEAST Small ribosomal subunit protein uS12A (Gene Name=RPS23A)

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