Structure of PDB 6g4s Chain X Binding Site BS01

Receptor Information

>6g4s Chain X (length=141) Species: 9606 (Homo sapiens)

GKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIV
LEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVL
VAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPR

Ligand information

>6g4s Chain 2 (length=1613)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucucucucggccgaagcguuuacuuugaaaaaauuagagug
uucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggacc
gcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggac
ggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggc
gcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaauca
agaacgaaagucggagguucgaagacgauaccgucguaguuccgaccaua
aacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggc
agcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaa
agcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccu
gcggcuuaauuugacucaacacgggaaaccucacccggcccggacacgga
caggauugacagauugauagcucuuucucgauuccgugggugguggugca
uggccguucuugguggagcgauuugucugguuaauuccgauaacggacuc
uggcaugcuauucuuagagggacaaguggcguucagccacccgagauuga
gcaauaacaggucugugaugcccuguccggggcugcacgcgcgcuacacu
gacuggcucagcguguccuacgccggcaggcgcggguaacccguugaacc
ccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaa
uucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuu
uguacaccgcgucgcuacuaccgauuggaugguuuagugaggcccucgga
ucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuu
gacuaucuagaggaaguaaaagucggguuuccguaggugaaccugcggaa
ggaucauuaacgg

...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<......<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>....>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<<<<<<....>>>>..
.>>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<.<<.<<<....>>>.>>..>>>.>>>......<<..<.......
....>..>>.........<<<<<((......<<<<.....<<..))>>..
.....>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<...<<.<<<<>>>>>>...<<<<<<.<.......<<...<.
......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<
.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<
<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>
>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>..
.>>.>....<<<<<<<...<...<<<<....>>>>...>>>>>>>>....
......<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>.
.>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....
>>>>....>>>..)))).]..<<<.<<<<<<<..<<..<<<<<.<<<<.<
<<<<<.......<........>...........<<<<<.<....<<<<<<
.......<..<<<........>>>..>.....>>>>>>......<<<.<<
<<<<<<<.....<<<<<....>>>...<<<......>>>...>>...<<<
...<...<<......>>..>.....<<<<<.....>>>>>........>>
>.....>>.>>>>.>>>..>>>..>.>>>>>...>>.>>>>.>>>.>...
<<.<<<........<.<<<.<<<<....>>>>.>>>....>.........
>>>.>>......<.....<<<<<..........>>>>>.....>.....>
>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>
>>>..<<<.<<....<<<<.<<....<<<<<<<<.<<<..<<<<.<<...
<<<<<<<<<<<<<<<<>>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.
>>>>>>>>...>>.>>>>.....>>>>><<<<<<<<<....>>>>>>>>>
.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6g4s Visualizing late states of human 40S ribosomal subunit maturation.
• Resolution: 4.0 Å
• Binding residue (original residue number in PDB): C4 R8 H23 A47 K48 S64 I66 K76 P86 D88 G104 F105 G106 K108 G113
• Binding residue (residue number reindexed from 1): C3 R7 H22 A46 K47 S63 I65 K75 P85 D87 G103 F104 G105 K107 G112

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0034063 stress granule assembly
• GO:0042274 ribosomal small subunit biogenesis
• GO:1990145 maintenance of translational fidelity

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005791 rough endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6g4s, PDBe:6g4s, PDBj:6g4s
• PDBsum: 6g4s
• PubMed: 29875412
• UniProt: P62266|RS23_HUMAN Small ribosomal subunit protein uS12 (Gene Name=RPS23)