Structure of PDB 4zu6 Chain X Binding Site BS01

Receptor Information

>4zu6 Chain X (length=309) Species: 71421 (Haemophilus influenzae Rd KW20)

MAIYADNSYSIGNTPLVRLKHFGHNGNVVVKIEGRNPSYSVKCRIGANMV
WQAEKDGTLTKGKEIVDATSGNTGIALAYVAAARGYKITLTMPETMSLER
KRLLCGLGVNLVLTEGAKGGAIAKAEEIVASDPSRYVMLKQFENPANPQI
HRETTGPEIWKDTDGKVDVVVAGVGTGGSITGISRAIKLDFGKQITSVAV
EPVESPVISQTLAGEEVKPGPHKIQGIGAGFIPKNLDLSIIDRVETVDSD
TALATARRLMAEEGILAGISSGAAVAAADRLAKLPEFADKLIVVILPSAS
ERYLSTALF

Ligand information

>4zu6 Chain B (length=4) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2)

FEYG

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4zu6 Crystal Structure of O-Acetylserine Sulfhydrylase from Haemophilus inuen-zae in complex with pre-reactive o-acetyl serine and peptide inhibitor
• Resolution: 2.03 Å
• Binding residue (original residue number in PDB): S70 T95 M96 K118 G119 P223 H224 K225 A231
• Binding residue (residue number reindexed from 1): S70 T95 M96 K118 G119 P221 H222 K223 A229

Enzymatic activity

• Enzyme Commision number: 2.5.1.47: cysteine synthase.

Gene Ontology

Molecular Function

• GO:0004124 cysteine synthase activity
• GO:0016740 transferase activity
• GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
• GO:0080146 L-cysteine desulfhydrase activity

Biological Process

• GO:0006535 cysteine biosynthetic process from serine
• GO:0019344 cysteine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4zu6, PDBe:4zu6, PDBj:4zu6
• PDBsum: 4zu6
• UniProt: P45040|CYSK_HAEIN Cysteine synthase (Gene Name=cysK)