Structure of PDB 4nu8 Chain X Binding Site BS01

Receptor Information
>4nu8 Chain X (length=311) Species: 71421 (Haemophilus influenzae Rd KW20) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAIYADNSYSIGNTPLVRLKHFGHNGNVVVKIEGRNPSYSVKCRIGANMV
WQAEKDGTLTKGKEIVDATSGNTGIALAYVAAARGYKITLTMPETMSLER
KRLLCGLGVNLVLTEGAKGMKGAIAKAEEIVASDPSRYVMLKQFENPANP
QIHRETTGPEIWKDTDGKVDVVVAGVGTGGSITGISRAIKLDFGKQITSV
AVEPVESPVISQTLAGEEVKPGPHKIQGIGAGFIPKNLDLSIIDRVETVD
SDTALATARRLMAEEGILAGISSGAAVAAADRLAKLPEFADKLIVVILPS
ASERYLSTALF
Ligand information
>4nu8 Chain A (length=8) Species: 90370 (Salmonella enterica subsp. enterica serovar Typhi) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
TFEYGDGI
Receptor-Ligand Complex Structure
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PDB4nu8 Crystal structure of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with high affinity inhibitory peptide from serine acetyl transferase of Salmonella Typhimurium at 2.0 A
Resolution2.07 Å
Binding residue
(original residue number in PDB)		T69 S70 G71 T73 M120 F144 P223 H224 Q227 G228 A231
Binding residue
(residue number reindexed from 1)		T69 S70 G71 T73 M120 F144 P223 H224 Q227 G228 A231
Enzymatic activity
Enzyme Commision number 2.5.1.47: cysteine synthase.
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0019344 cysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4nu8, PDBe:4nu8, PDBj:4nu8
PDBsum4nu8
PubMed
UniProtP45040|CYSK_HAEIN Cysteine synthase (Gene Name=cysK)

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