Structure of PDB 3jb9 Chain X Binding Site BS01

Receptor Information
>3jb9 Chain X (length=1195) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKKQIINYANSNWGEGVEFQETMLQCILEAVIVSAKQVLSLLHELKLFEN
FLWQRVNTEMSLNHINLTCMLLLYKSKYEYITWDLINRFQLFFEKVIEVS
LSLNLSEVVYMIQFITLCFQFSNIEKLRKLVYQLTNISILNSLLDKVKYL
LHDSSSLTKAFDSYKEKRPVEKFPLHNLLSRWIHSLLIKSISYAQKQEAK
VTPLLAIINMSLVLLSAFPTRRFAHPVIEDSCFYTALRMSLYYDSNELFK
KMTDDLNYVLKFPFDNTRGNEYEKEQKIRNDELVYYHLQLTLFSDFQLQQ
RQKLEEITSFLSFNSLKSLCSKCYLRTSFPEKYAIKVDFEFLKNVFINTY
DRRLVNDYDEIINFTLKDVLGERSVMDQENSLTNTAIQYLSISFFMRQQS
KAYKKLLLRSLYAELLNFSEQYRRLSIKNATKNLNFFSLNNFKVTSVAPL
PQFVKCQMGLSRPSALRDLKNSSPFLCLIYISKDMEYKLLHGNALDPLEV
TDFTIATICNDDVGMFMQSDSDNKSINVYLSPFYYHSLAGLGEYRPKQLK
FNFALVLSNKYWLDLNILVSLLNRAKEFPKWFEDLFLGFGTPDICAFPNA
NSIYARNLFNTVEQLQSVLPNCHVPSNLSTESLLIKFYTNQNKSADVTAS
DRHFSNRLYTYNDKQLESILRGSQPGLTMVNGPTRCGKHVLVCKLLEVLQ
DTSPNDRTVVLSDSNFSMNTLFTLLEKARCFHHLLYLSDEGTLERYGTLS
SWISKLPGLLREIGRLAASIQAPGSHDASPDTALYFRDAYIKRLWEKYLN
TVDKDSVDAYNRFPFHSYFGDKSKRPIETYNKDNFFDYATKLYGELEYMF
QQLEEIRPFGLLRYYEDQELYALCQQSRIIGCTWTSLSTRLGTLKEKGFC
FNNLIVMNSQNISESSITSILLSNCEPTGFDRLVLLGNQYNGSLFKRLRY
LKSRIIDLNTQYNVRESISSLCSSIYPLDIKTVDSSPNKRLDYGNSGFAH
EVQFINVGAFKGSQETEPVSGYKQNLGEAEYAVALFQYMRMLGYPTNEIV
ICTLYESQVSLLNEIISVRCSHNSFFGQPAFVGTVEKLPKRVNFVIFTTV
ESKEASDHWNPKTFYKAFSACSYGLYVLCNRDLFRSTRGLEKLWNEIEKT
PDKLLLTTGEIYPSSHSSVETFEIENLLHLSNYVVEMTKKRLNTN
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain3jb9 Chain X Residue 1500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3jb9 Structure of a yeast spliceosome at 3.6-angstrom resolution
Resolution3.6 Å
Binding residue
(original residue number in PDB)		Y725 T726 R751 C752 G753 H755 Y1046 T1066
Binding residue
(residue number reindexed from 1)		Y659 T660 R685 C686 G687 H689 Y962 T982
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045292 mRNA cis splicing, via spliceosome
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0071013 catalytic step 2 spliceosome
GO:0071014 post-mRNA release spliceosomal complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3jb9, PDBe:3jb9, PDBj:3jb9
PDBsum3jb9
PubMed26292707
UniProtO94508|CWF11_SCHPO Pre-mRNA-splicing factor cwf11 (Gene Name=cwf11)

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