Structure of PDB 2nv2 Chain X Binding Site BS01

Receptor Information
>2nv2 Chain X (length=195) Species: 1423 (Bacillus subtilis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLILPGGEST
TMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLL
NVVVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLS
EHNGRIVAAKQGQFLGCSFNPELTEDHRVTQLFVEMVEEYKQKAL
Ligand information
Ligand IDGLN
InChIInChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
InChIKeyZDXPYRJPNDTMRX-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(=O)N)C(C(=O)O)N
OpenEye OEToolkits 1.5.0C(CC(=O)N)[C@@H](C(=O)O)N
ACDLabs 10.04O=C(N)CCC(N)C(=O)O
CACTVS 3.341N[CH](CCC(N)=O)C(O)=O
CACTVS 3.341N[C@@H](CCC(N)=O)C(O)=O
FormulaC5 H10 N2 O3
NameGLUTAMINE
ChEMBLCHEMBL930
DrugBankDB00130
ZINCZINC000001532526
PDB chain2nv2 Chain X Residue 6048 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2nv2 Structure of a bacterial pyridoxal 5'-phosphate synthase complex
Resolution2.12 Å
Binding residue
(original residue number in PDB)		G46 G47 C79 A80 I83 R106 I134
Binding residue
(residue number reindexed from 1)		G46 G47 C79 A80 I83 R106 I134
Annotation score5
Enzymatic activity
Enzyme Commision number 3.5.1.2: glutaminase.
4.3.3.6: pyridoxal 5'-phosphate synthase (glutamine hydrolyzing).
Gene Ontology
Molecular Function
GO:0004359 glutaminase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0036381 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
GO:0042802 identical protein binding
Biological Process
GO:0006541 glutamine metabolic process
GO:0006543 glutamine catabolic process
GO:0008614 pyridoxine metabolic process
GO:0042819 vitamin B6 biosynthetic process
GO:0042823 pyridoxal phosphate biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:1903600 glutaminase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2nv2, PDBe:2nv2, PDBj:2nv2
PDBsum2nv2
PubMed17159152
UniProtP37528|PDXT_BACSU Pyridoxal 5'-phosphate synthase subunit PdxT (Gene Name=pdxT)

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