Structure of PDB 2h7f Chain X Binding Site BS01

Receptor Information
>2h7f Chain X (length=314) Species: 10255 (Variola virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRALFYKDGKLFTDNNFLNPVSDNNPAYEVLQHVKIPTHLTDVVVYGQTW
EEALTRLIFVGSDSKGRRQYFYGKMHVQNRNAKRDRIFVRVYNVMKRINS
FINKNIKKSSTDSNYQLAVFMLMETMFFIRFGKMKYLKENETVGLLTLKN
KHIEISPDKIVIKFVGKDKVSHEFVVHKSNRLYKPLLKLTDDSSPEEFLF
NKLSERKVYESIKQFGIRIKDLRTYGVNYTFLYNFWTNVKSISPLPSPKK
LIALTIKQTAEVVGHTPSISKRAYMATTILEMVKDKNFLDVVSKTTFDEF
LSIVVDHVKSSTDG
Ligand information
Receptor-Ligand Complex Structure
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PDB2h7f Structural basis for specificity in the poxvirus topoisomerase.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		Y70 Y72 R80 R206 K220 A273 Y274
Binding residue
(residue number reindexed from 1)		Y70 Y72 R80 R206 K220 A273 Y274
Enzymatic activity
Catalytic site (original residue number in PDB) R130
Catalytic site (residue number reindexed from 1) R130
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2h7f, PDBe:2h7f, PDBj:2h7f
PDBsum2h7f
PubMed16885024
UniProtP32989|TOP1_VAR67 DNA topoisomerase 1 (Gene Name=OPG111)

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