Structure of PDB 2f8e Chain X Binding Site BS01

Receptor Information
>2f8e Chain X (length=474) Species: 12116 (Foot and mouth disease virus C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALE
Ligand information
>2f8e Chain A (length=15) Species: 110195 (Foot-and-mouth disease virus Asia 1) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GPYAGPLERQRPLKV
Receptor-Ligand Complex Structure
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PDB2f8e The structure of a protein primer-polymerase complex in the initiation of genome replication
Resolution2.9 Å
Binding residue
(original residue number in PDB)		K164 E166 I167 R168 P169 K172 R179 G216 C217 D240 Y336 K387 R388 T407 I411 L430
Binding residue
(residue number reindexed from 1)		K164 E166 I167 R168 P169 K172 R179 G216 C217 D240 Y336 K387 R388 T407 I411 L430
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2f8e, PDBe:2f8e, PDBj:2f8e
PDBsum2f8e
PubMed16456546
UniProtQ0QEE0

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