Structure of PDB 2agg Chain X Binding Site BS01

Receptor Information
>2agg Chain X (length=223) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRL
GEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRV
ASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKS
AYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQK
NKPGVYTKVCNYVSWIKQTIASN
Ligand information
Receptor-Ligand Complex Structure
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PDB2agg Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates
Resolution1.28 Å
Binding residue
(original residue number in PDB)		H57 D189 S190 C191 Q192 S195 S214 W215 G216 S217
Binding residue
(residue number reindexed from 1)		H40 D171 S172 C173 Q174 S177 S192 W193 G194 S195
Enzymatic activity
Catalytic site (original residue number in PDB) G193 S195 G196
Catalytic site (residue number reindexed from 1) G175 S177 G178
Enzyme Commision number 3.4.21.4: trypsin.
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
GO:0097655 serpin family protein binding
Biological Process
GO:0006508 proteolysis
GO:0007586 digestion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0097180 serine protease inhibitor complex

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Biological Process
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Cellular Component
External links
PDB RCSB:2agg, PDBe:2agg, PDBj:2agg
PDBsum2agg
PubMed16636277
UniProtP00760|TRY1_BOVIN Serine protease 1 (Gene Name=PRSS1)

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