Structure of PDB 1z3i Chain X Binding Site BS01

Receptor Information

>1z3i Chain X (length=644) Species: 7955 (Danio rerio)

LGLRRAGVRKALHDPFEDGALVLYEPPAISAHDLIKADKEKLPVHVVVDP
VLSKVLRPHQREGVKFLWDCVTGRRIENSYGCIMADEMGLGKTLQCITLI
WTLLKQSPDCKPEIDKVIVVSPSSLVRNWYNEVGKWLGGRVQPVAIDGGS
KDEIDSKLVNFISQQGMRIPTPILIISYETFRLHAEVLHKGKVGLVICDE
GHRLKNSDNQTYLALNSMNAQRRVLISGTPIQNDLLEYFSLVHFVNSGIL
GTAQEFKKRFEIPILKGRDADASDKDRAAGEQKLQELISIVNRCLIRRTS
DILSKYLPVKIEQVVCCNLTPLQKELYKLFLKQAKPVESLQTGKISVSSL
SSITSLKKLCNHPALIYEKCLTGEEGFDGALDLFPQNYSTKAVEPQLSGK
MLVLDYILAMTRTTTSDKVVLVSNYTQTLDLFEKLCRNRRYLYVRLDGTM
SIKKRAKIVERFNNPSSPEFIFMLSSKAGGCGLNLIGANRLVMFDPDWNP
ANDEQAMARVWRDGQKKTCYIYRLLSTGTIEEKILQRQAHKKALSSCVVD
EEQDVERHFSLGELRELFSLNEKTLSDTHDRFRCRRCVNGRQVRPPPDDS
DCTCDLSNWHHCADKRGLRDPVLQASWDAAVSFVFHQRSHEDQR

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 1z3i Chain X Residue 900

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1z3i Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): H670 C675 C678 H702
• Binding residue (residue number reindexed from 1): H579 C584 C587 H611
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.12: DNA helicase.

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0140658 ATP-dependent chromatin remodeler activity

External links

• PDB: RCSB:1z3i, PDBe:1z3i, PDBj:1z3i
• PDBsum: 1z3i
• PubMed: 15806108
• UniProt: F1Q8K0|RAD54_DANRE DNA repair and recombination protein RAD54-like (Gene Name=rad54l)